In addition, FPP-3 administration dramatically increased the hepa

In addition, FPP-3 administration dramatically increased the hepatotoxicity parameters in serum at 500 mg/kg, in association of hepatic necrosis. FPP-3 significantly induced several phase I enzyme activities. To elucidate the possible mechanism(s) involved in FPP-3 induced hepatotoxicity, we investigated the hepatic activities of free radical generating and scavenging enzymes and the level of hepatic lipid peroxidation. FPP-3 treatment significantly elevated the hepatic lipid peroxidation,

measured as the thiobarbituric acid-reactive substance, and the activity of superoxide dismutase. Taken together, the present data VX-809 Transmembrane Transporters inhibitor indicated that reactive oxygen species might be involved in FPP-3-induced hepatotoxicity.”
“Background: Malassezia (M.) species are members of the normal part of the skin flora, but they might induce or be involved with various cutaneous diseases. Although Ubiquitin inhibitor the role of Malassezia in the pathogenesis of cutaneous diseases is not fully understood, recent studies have shown that decreased density of Malassezia led to improvement of these diseases.

Objective: To identify the antifungal effect of light emitting diode (LED) against Malassezia, its antifungal mechanisms and the impact on the keratinocytes.

Methods: LED with various wavelengths (370-630 nm) on Malassezia furfur, Malassezia sympodialis and Malassezia

globosa was irradiated according to dose and then the antifungal effects were thereafter assessed. After irradiating LED with 392.5 +/- 1 nm of wavelength according to dose on Malassezia species, reactive oxygen species (ROS) and lipid hydroperoxide production assay were measured. In addition, cell viability and inflammatory cytokines (IL-1 alpha., IL-1 beta, TNF-alpha, TGF-beta, TLR-2 and COX-2) expressions in normal human epidermal keratinocytes (NHEKs) by LED irradiation were evaluated.

Results: The growth of

Malassezia Cl-amidine in vitro species was dose-dependently suppressed by both LED with 380 +/- 2 and 392.5 +/- 1 nm wavelengths. The increases of intracellular and extracellular ROS by LED irradiation with 392.5 +/- 1 nm wavelengths were significantly observed compared to control group. The cell viability and cytokines in NHEKs were not significantly affected by LED irradiation under 5 J/cm(2) in vitro.

Conclusion: LED irradiation with 380 +/- 2 and 392.5 +/- 1 nm wavelengths proved to have antifungal effect against Malassezia species and no impact on NHEKs under 5 J/cm(2). The findings suggest that LED might be an adjunctive therapeutic light tool against Malassezia yeasts related cutaneous diseases. (C) 2012 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.”
“The entanglement of lignin polymers with cellulose and hemicellulose in plant cell walls is a major biological barrier to the economically viable production of biofuels from woody biomass.

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001) comparable to the standard drug diclofenac sodium at the dos

001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The crude extract produced the most prominent cytotoxic activity against brine shrimp Artemia sauna (LC50 = 5.5 mu g/ml and LC90 = 9.3 mu g/ml). The extract showed antidiarrhoeal activity on castor oil induced

diarrhoea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the Selleck Vorinostat oral dose of 250 and 500 mg/kg body weight (P < 0.01) comparable to the standard drug Loperamide at the dose of 50 mg/kg of body weight. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.”
“To investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population.

A total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case-control study and case-only Z-DEVD-FMK mw study were performed to define the contribution

of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.

A significant association of rs11190870 with AIS was AZD6738 cost observed in the Han Chinese population (P = 1.8 x 10(-9); odd ratio = 1.51; 95 % confidence interval = 1.33-1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population.

The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.”
“Diabetes mellitus is a metabolic disease associated to oxidative stress. In this work, the hypoglycaemic and antioxidant effect of an extract of Physalis peruviana fruits in an experimental diabetes model was evaluated. The diabetes was induced in Wistar rats

by a single administration of streptozotocin. The oxidative stress markers evaluated were lipid peroxidation, protein oxidation, ferric reducing ability of plasma (FRAP) and the superoxide dismutase and catalase activities in pancreas, liver and kidney. The oral administration of Physalis peruviana extract during 15 days reduced the blood glucose levels further than 30 %. The same way, the extract administration increased the FRAP levels and the superoxide dismutase and catalase activities. The lipid peroxidation and protein oxidation levels were reduced. The results suggest that the Physalis peruviana extract exhibit hypoglycaemic activity and improve the antioxidant status of the streptozotocin diabetic animals.

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IL-8 secretion was transiently increased after CRLP treatment, an

IL-8 secretion was transiently increased after CRLP treatment, and CRLP maintained secretion in the presence of pharmacological inhibitors of IL-8 production. In contrast, exposure to CRLP significantly reduced MCP-1 secretion. Chemotaxis towards MCP-1 was increased in monocytes pre-exposed to CRLP and was reversed by addition of exogenous MCP-1.

Conclusion: Our findings indicate that CRLP activate human monocytes and augment their migration in vitro by reducing cellular MCP-1 expression. Our data support the current hypothesis that CMR contribute to the inflammatory milieu of the arterial wall

in early atherosclerosis, and suggest that this may reflect direct interaction with circulating blood monocytes. Selleckchem BI 2536 (C) 2010 Elsevier B.V. All rights reserved.”
“Study Design. Study analyses dimensions, angular orientations, and symmetry of articular facets at the L5-S1 junction associated with transitional anomalies comprising (1) L5-S1 accessory articulations; (2) complete sacralization of the L5 vertebrae; and (3) completely lumbarized S1 sacral segments. Data were compared with same parameters evaluated in normal sacrum.

Objective. Investigating

probable morphologic differences in facet joints at the normal and transition affected lumbosacral junctions.

Summary of Background Data. Facet joints at the L5-S1 play an important learn more role in load sharing and imparting stability at this area as well as are involved in conditions such as isthmic spondylolysis, degenerative spondylolisthesis, and osteoarthritis, giving rise to low back pain situations. Several morphologic variations at the lumbosacral Caspase-8 Inhibitor junction have been studied and inconsistently alluded to be associated with these painful conditions. Lumbosacral transitional anomalies, on the other hand, have also been linked to low back pain situations.

L5-S1 transitions have been shown to be associated with altered L5-S1 articular morphology as well as load-sharing pattern at the region. The analysis of L5-S1 zygapophysial anatomy in context of transitional anomalies at this region has rarely been documented.

Methods. Both the superior articulating facets in the normal as well as in transition associated sacra were measured for (1) height, (2) width, (3) surface area, and (4) angulation of the articular surfaces with reference to the midsagittal plane. Data were also analyzed to find structural asymmetry between the two sides.

Results. Facets demonstrated smallest linear dimensions, surface areas, and maximum coronal orientation in lumbarized specimens. Facets areas associated with accessory articulations were also smaller and coronally oriented. Sacralization induced insignificant alteration in the facet morphology. Asymmetry (tropism) was observed in facets predominantly associated with accessory L5-S1 articulations.

Conclusions. L5-S1 transitions possess altered facet morphology.

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week 1 vs week 24: 11 6 +/- 0 5 vs 9 0 +/- 0 5 vs 8 6 +/- 0 5

week 1 vs. week 24: 11.6 +/- 0.5 vs. 9.0 +/- 0.5 vs. 8.6 +/- 0.5 mmol/L and 1,999 +/- 85 vs. 1,536 +/- 51 vs. 1,538 +/- 72 mmol/L/min, both p < 0.01). In parallel, the glucagon response decreased (23,762 +/- 4,732 vs. 15,989 +/- 3,193 vs. 13,1207 learn more +/- 1,946 pg/mL/min, p < 0.05) and the GLP-1 response increased (4,440 +/- 249 vs. 6,407 +/- 480 vs. 6,008 +/- 429 pmol/L/min, p < 0.01). The GIP response was decreased at week 24 (baseline-115,272 +/- 10,971 vs. week 24-88,499 +/- 10,971 pg/mL/min, p < 0.05). Insulin levels did not change significantly. Glycemic control was still improved 1 week after explantation.

The data indicate DJBL to be a promising treatment

for obesity and type 2 diabetes, causing rapid improvement of glycemic control paralleled by changes in gut hormones.”
“A four-stage procedure for the isolation

of the ChGC from the biomass of natural fungi-the honey mushroom (Armillariella mellea) and the yellow morel (Morchella esculenta), belonging to the classes Basidiomycetes and Ascomycetes, respectively, has been developed. The isolation procedure included deproteinization (2% NaOH + 0.1% sodium stearate, 83-85A degrees C, 2 h), demineralization (1% HCl, 55-60A degrees C, 2 h), depigmentation (5% H(2)O(2) in ammonia (30-35A degrees C, 4 h)), and deglucanization (2% NaOH, 83-85A degrees C, 2 h). The original raw material and the chitin-containing materials were characterized on the basis find more of results of Fourier transform infrared spectroscopy, X-ray analysis, and pyrolytic gas chromatography using crustacean chitin as a reference compound. The content of chitin in the final products was 70% for

A. mellea and 50% for M. esculenta. The possibility of obtaining chitin-containing materials with the required properties SB273005 by selecting the fungal species and treatment conditions (the succession and repetition of certain stages) is demonstrated.”
“Open techniques represent a valid repair option for severe asymmetric pectus excavatum in adults. The use of metal supports is recommended to reduce the risk of recurrence. A wide variety of metal supports have been proposed, with pre-, trans- or retrosternal fixation. A novel open technique using titanium bars fixed to the ribs with clips has been recently introduced (STRATOS (TM) system) for chest wall reconstruction, rib fracture fixation and chest wall malformation repair. We employed this technique in two adult patients with severe asymmetric pectus excavatum: after sternal mobilization, one bar is passed below the body of the sternum and secured with clips bilaterally to two ribs. In the first case, the results remained excellent 5 years after surgery. In the second case, the initial results were satisfying but the bar ruptured after 30 months: removal of the bars and clips was performed and a subsequent recurrence of the deformity occurred.

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As a consequence, bacterial abundance would also increase and

As a consequence, bacterial abundance would also increase and

reinforce the already dominant role of microbes in the carbon cycle of a warmer ocean.”
“In this work, five ternary blends based on 70% by weight (wt %) of polypropylene (PP) with 30% wt of polycarbonate (PC)/poly(styrene-b-(ethylene-co-butylene)-b-styrene)(SEBS) dispersed phase consists of 15 wt % PC and 15 wt % reactive (maleic anhydride grafted) and nonreactive SEBS mixtures at various ratios were prepared in a co-rotating twin screw extruder. scanning electron microscopy (SEM) micrographs showed that the blends containing only nonreactive SEBS exhibited a fine dispersion of core-shell particles. With decreasing the SEBS/SEBS-g-Maleic Anhydride (MAH) weight ratio, the morphology changed from the core-shell particles to a mixed of core-shell, rod-like and individual particles. GSK461364 molecular weight This variation in phase morphology affected

the thermal and mechanical properties of the blends. DSC results showed that the blends containing only nonreactive SEBS exhibited a minimum in degree of crystallinity due to the homogeneous nucleation of core-shell particles. Mechanical testing showed that in the SEBS/SEBS-g-MAH weight ratio of 50/50, the modulus Y-27632 in vitro and impact strength increased compared with the PP matrix while the yield stress had minimum difference with that of PP matrix. These effects could be attributed to the formation of those especial microstructures revealed by the SEM studies. (C) 2011 Wiley Periodicals,

Inc. J Appl Polym Sci 121: 2680-2687, 2011″
“The effects of biaxial strain on the electrical and magnetic properties of an antiferromagnetic Heusler compound Fe2VSi were systematically investigated. A series of epitaxial Fe2VSi thin films on MgAl2O4 and MgO substrates were fabricated with different tensile strains by varying the substrate-lattice mismatch and the film thickness. The strain was characterized by the ratio of the out-of-plane lattice parameter c to the in-plane lattice parameter a; this ratio c/a varied from 0.987 to 0.998 at room temperature. The tensile epitaxial strain was found to increase the antiferromagnetic Neel temperature T-N to 193 K, which is 70 K higher than that for the unstrained bulk material. A clear dependence check details of T-N on c/a was observed, which is consistent with theoretical predictions in which the band Jahn-Teller effect plays a significant role. (C) 2011 American Institute of Physics. [doi:10.1063/1.3555089]“
“This study investigated the mechanism underlying the effect of tripterine on apoptosis of human acute myelocytic leukemic cells (HL-60). The apoptosis of HL-60 cells after treatment with triperine of different dosages and durations were determined using flow cytometry and transmission electron microscopy. The expressions of Fas, FasL and NF-KB in the HL-60 cells treated with 1.5 mu mol/L tripterine for different durations were measured by flow cytometry. Our results showed treatment with 0.5 similar to 2.

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Conclusion: Only the psychological approach to successful ageing

Conclusion: Only the psychological approach to successful ageing independently predicted QoL at follow-up. Successful ageing is not only about the maintenance of health,

but about maximising one’s psychological resources, namely self-efficacy and resilience. Increasing use of preventive care, better medical management of morbidity, and changing lifestyles in older people may have beneficial effects on health and longevity, but may not improve their QoL. HIF inhibitor Adding years to life and life to years may require two distinct and different approaches, one physical and the other psychological. Follow-up health status, number of supporters and social activities, and self-rated active ageing also significantly predicted QoL at follow-up. The longitudinal sample bias towards healthy survivors is likely to underestimate these results.”
“The correlations between Compound Library high throughput the hardness, yield stress, and modulus of elasticity of isotactic polypropylene (iPP) were evaluated on the local and global scales. Nanoindentation and traditional macromechanical tests were incorporated for this purpose. Thus, local and global mechanical properties were measured at various temperatures and strain rates. A certain relation was found between the local and global mechanical properties. Moreover, Johnson’s model (developed according to the expanding cavity model) was also evaluated at various temperatures and strain rates. The Johnson model

was valid only for the yield stresses obtained by nanoindentation and compressive tests and also the elastic modulus obtained via nanoindentation. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 121: 930-938, 2011″
“Although behavioral approaches cannot be seen as offering a panacea for all emotional ills, the assumption upon which they are based make their integration with physiological concepts a natural and comfortable union. The application of behavioral treatments for psychosomatic disturbances has been developed in the last 30 years favouring

the organization of clinical protocols this website of treatment more standardized and scientifically proved in particular in headache field where the behavioral approach is actually an important therapeutical support for traditional pharmacological approaches. The different therapeutical approaches, initial outcomes are discussed.”
“Background: In spite of enhanced control efforts, malaria remains a major public health problem causing close to a million deaths annually. With support from several donors, large amounts of artemisinin-based combination therapy (ACT) are being deployed in endemic countries raising safety concerns as little is known about the use of ACT in several of the settings where they are deployed. This project was undertaken to profile the provenance of the pharmacovigilance reporting of all anti-malarials, including ACT to the WHO adverse drug reaction (ADR) database (Vigibase (TM)) over the past 40 years.

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These dissimilar results may be due to chemical differences betwe

These dissimilar results may be due to chemical differences between them. Thus, we demonstrated that 1 and 2 seem to be promising spasmolytic agents, although further studies are required GS-9973 in vitro to elucidate the spasmolytic action mechanism.”
“Aims: To evaluate the prognostic value of immunohistochemical

expression of Bcl-2 in colon cancers.

Patients and methods: Two hundred and twenty-six resected and paraffin-embedded colon carcinomas were analysed by immunostaining using monoclonal antibodies for Bcl-2. We evaluated whether the Bcl-2 staining patterns, semi-quantitatively assessed, could be correlated with the pTNM stage, size and tumour circumference, differentiation, appearance, vascular invasion, perineural invasion, colloid Dactolisib purchase component, margins, involvement of adjacent structures, stromal appearance, flow cytometry and the S-phase.

Results: Eighty patients (36%) were considered Bcl-2 positive. The extent of Bcl-2 expression by tumour cells decreased significantly with respect to increasing tumour size (P = 0.042), the extension of parietal. invasion pT (P 0.007), the invasive

nature of the tumour (P = 0.024), and extent of the circumference (P = 0.024). In a multivariate analysis, Bcl-2 expression does not appear as an independent prognosis factor in the overall population as in the 166 patients with optimal resection. Of the 59 stage II patients, using univariate analysis, Bcl-2 appears to be predictive of relapse-free survival (P = 0.025) but not of overall survival (P = 0.09).

Conclusion: The loss of Bcl-2 expression appears to be correlated with increase in number of relapses in the stage II colon cancers and could be a potential useful additional histo-prognostic marker in therapy decision making.

Bcl-2 immunodetection seems to be associated with slower local tumour growth. (C) 2008 Elsevier Ltd. All rights reserved.”
“Objective: The pathophysiology of anterior cruciate ligament (ACL) rupture leading to knee osteoarthritis (OA) remains largely unknown. selleckchem It seems that bone loss occurs after ACL rupture. The purpose of our study was to determine bone mineral density (BMD) changes in the knee after ACL rupture during 2-year follow-up period and to compare BMD changes between the injured and healthy contralateral knee.

Design: Patients were included in an observational prospective follow-up study within 6 months after ACL trauma and evaluated for 2 years. Patients were treated operatively or non-operatively. At baseline and at the one- and 2-year follow-ups, BMD was measured in six regions of the tibia and femur for both knees (medial, central, lateral) using a Dual-energy X-ray Absorptiometry (DXA) scanner.

Results: One hundred forty-one patients were included, with the following characteristics: 66% were male, median age at baseline was 25.3 (inter-quartile range 11.3) years, and 63% were treated operatively.

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In addition, the web site (http://peroxibase isb-sib ch) provides

In addition, the web site (http://peroxibase.isb-sib.ch) provides a series of bioinformatics tools and facilities suitable for analysing these stored sequences. In particular, the high number of isoforms in each organism makes phylogenetic studies extremely INCB28060 solubility dmso useful to elucidate the complex evolution of these enzymes, not only within

the plant kingdom but also between the different kingdoms. This paper provides a general overview of PeroxiBase, focusing on its tools and the stored data. The main goal is to give researchers some guidelines to extract classified and annotated sequences from the data base in a quick and easy way in order to perform alignments and phylogenetic analysis. The description of the database is accompanied by the updates we have recently carried out in order to improve its completeness and make it more user-friendly.”
“Study Design. We describe an innovative single-stage reduction and stabilization technique using modern cervical instrumentation.

Objective. We hypothesis modern instrumentation has made more aggressive surgical corrections possible and has reduced the need for transoral resection of the odontoid and traction reduction in children with basilar invagination.

Summary of Background Data. Craniocervical junction abnormalities, including atlantoaxial instability and progressive basilar invagination, selleck compound are

relatively common phenomenon in Down’s syndrome patients, and can lead to chronic progressive neurologic deficits, catastrophic injury, and death. This patient population also can be a difficult one in which to perform successful stabilization and fusion.

Methods. We reviewed the records and films on 2 children with Down’s syndrome and atlantoaxial instability who had undergone prior occipital-cervical fusion and then presented with symptomatic progressive basilar invagination due to atlantoaxial displacement. In both cases,

the children had progressive symptoms of spinal cord and brain stem compression. Multiple approaches for surgical correction, including preoperative traction and transoral odontoid resection, were considered, but ultimately it was elected to perform a single stage posterior operation. In both patients, we performed fusion take-down, intraoperative realignment Pevonedistat molecular weight with reduction of the basilar invagination, and stabilization using modern occipito-cervical instrumentation.

Results. In both children, excellent cranio-cervical realignment was achieved; along with successful fusion and improvement in clinical symptoms.

Conclusion. In this article we will discuss the clinical cases and review the background of craniocervical junction abnormalities in Down’s syndrome patients. We hypothesis modern instrumentation has made more aggressive surgical corrections possible and has reduced the need for transoral resection of the odontoid and traction reduction in children with basilar invagination.

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The bacterial uptake of ofloxacin from hydrogels was higher than

The bacterial uptake of ofloxacin from hydrogels was higher than that obtained with a solution of free ofloxacin in both fluoroquinolone-sensitive and -resistant P. aeruginosa. The improved uptake in fluoroquinolone-resistant isolates was correlated with the viscosity of hydrogels. The performance of hydrogels seems to be related to their bioadhesive properties that allow prolonged contact time and find more the release of an effective

amount of drug close to bacterial cells. Hence, hydrogels could be used in the development of more effective formulations for topical administration of antibiotics. Improved performance of an old antibiotic can preserve the use of new generation fluoroquinolones.”
“Genital tuberculosis is often neglected by health-care providers, but is an important PP2 cell line cause of significant morbidity for the affected women.

We report a rare case of tuberculosis (TB) flare in a 28-year-old nulliparous woman following

endometrial aspiration (EA), which drained 30 ml pus. Following this, she developed high-grade fever with pain abdomen, guarding and rigidity. PCR was positive for mycobacterium and histopathology showed necrotizing granulomatous endometritis. She also showed features of genitourinary TB and chronic tubercular meningitis and was started on antitubercular therapy.

To conclude, EA requires concern and a higher precision in the diagnosis of this insidious disease that primarily necessitates a clinical awareness of this serious health problem, to prevent such flare-up of TB. The clinician should be aware that isolation of TB requires special methods and this diagnosis should be considered while dealing with patients born in countries with high prevalence

of TB.”
“Study Design. Case report.

Objective. We report the unusual case of a patient who was referred to our institution after she sustained an intraoperative injury to the common iliac vein during posterior lumbar discectomy at L5-S1 with a pituitary rongeur. There was only minimal bleeding with spontaneous hemostasis and no hemodynamic instability. Subsequently, the referring PD-L1 inhibitor surgeon noted that the pituitary rongeur tip was missing.

Summary of Background Data. Vascular injury during lumbar discectomy is a rare, but potentially devastating complication. Rapid diagnosis and treatment is traditionally targeted toward hemodynamic stabilization and repair of compromised structures.

Methods. Intraoperative fluoroscopy confirmed the presence of the tip anterior to the L3 vertebral body, indicating a possible intravascular migration of the foreign body. After completion of the surgical procedure, an abdominal computed tomography scan failed to confirm the metallic object within the abdominal cavity. Subsequent imaging studies demonstrated the presence of the rongeur tip in the left ventricle.

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Result: We studied 12 026 STEMI patients admitted to 68 hospital

Result: We studied 12 026 STEMI. patients admitted to 68 hospitals. The mean age was 64 +/- 13 years and 73% of the patients were male. Incidence of in-hospital death was 7.6% in 2000 and 6% in 2007. Reinfarction fell 3-MA in vivo from 3.7% in 2000 to 0.9% in 2007. Thrombolysis decreased from 40.2% in 2000 to 2% in 2007. Clinical predictors of mortality were: age > 65 years, Killips class III or IV, diabetes, Q wave myocardial infarction (at presentation). Patients undergoing percutaneous coronary intervention (PCI) had lower mortality and reinfarction rates (3.9% versus

11.2%, and 1.1% versus 3.1%, respectively, p < 0.001) over time, although their numbers increased from 43% in 2000 to 85% in 2007. Patients admitted to hospitals with PCI facilities had

lower mortality than patients hospitalised in hospitals without it, but the demographic characteristics differ between the two groups.

Both in-hospital mortality and reinfarction decreased significantly over the time, parallel to an increased number of PCI. PCI was also the strongest predictor of survival.

Conclusion: In-hospital mortality and reinfarction rate have decreased significantly in Swiss STEMI patients in the last seven years, parallel to a significant increase in the number APR-246 solubility dmso of percutaneous coronary interventions in addition to medical therapy. Outcome is not related to the site of admission but to PCI access.”
“A multiple graphene layer (MGL) structure with a stack of GLs and a highly conducting bottom GL on SiC substrate pumped by optical radiation is considered as an active region of terahertz and far infrared lasers with external metal mirrors. The dynamic conductivity of the MGL structure is calculated as a function of the signal frequency, the number of GLs, and the optical pumping intensity. The utilization of optically pumped MGL structures might provide the achievement of lasing with the frequencies of about 1 THz

at room temperature due to a high efficiency of pumping. (C) 2009 American Institute of Physics. [doi:10.1063/1.3247541]“
“In this study, a quantitative structure-pharmacokinetic relationship (QSPkR) model for the volume of distribution (V-d) values PND-1186 nmr of 126 anti-infective drugs in humans was developed employing multiple linear regression (MLR), artificial neural network (ANN) and support vector regression (SVM) using theoretical molecular structural descriptors. A correlation-based feature selection (CFS) was employed to select the relevant descriptors for modeling. The model results show that the main factors governing V-d of anti-infective drugs are 3D molecular representations of atomic van der Waals volumes and Sanderson electronegativities, number of aliphatic and aromatic amino groups, number of beta-lactam rings and topological 2D shape of the molecule. Model predictivity was evaluated by external validation, using a variety of statistical tests and the SVM model demonstrated better performance compared to other models.

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