05) and ‘perceptions of management’ (p < 0 01)

The

05) and ‘perceptions of management’ (p < 0.01).

The SAQ was successfully applied to an AMAU setting giving a valuable insight into staff issues of concern across the safety spectrum: employee and environmental safety, clinical risk management and medication safety.”
“In the aftermath of the Chernobyl nuclear power plant accident, a research group of the Italian National PP2 Angiogenesis inhibitor Institute of Health (Istituto Superiore di Sanita) carried out two research programmes on maternal milk. One concerned the transfer of caesium radionuclides

from the diet to breast milk. In the other, the activity concentrations of Cs-137 were also determined in urine and placenta. The first study estimated the mothers’ average Cs-137 Panobinostat clinical trial dietary intake, in the second study the intake was evaluated individually for each subject. In 2004, the International Commission on Radiological Protection published modified systemic biokinetic models which also account for transfer to breast milk. The model for caesium radionuclides was implemented and tested by the authors with the experimental data described above. A good agreement was obtained between measured data and model simulations of Cs-137

activity concentration in human milk. The model, however, tends to systematically overestimate Cs-137 activity concentration in urine, in which case the agreement is to be considered satisfactory in terms of order of magnitude. (C) 2011 Elsevier Ltd. All rights reserved.”
“Combined Fludarabine and Cyclophosphamide is now standard first-line therapy in chronic lymphocytic leukaemia (CLL) and the addition of Rituximab improves outcome.

We adopted a modified Fludarabine, Cyclophosphamide and Rituximab (FCR) protocol in treating 39 patients (median age 57 years) with progressive or advanced CLL. Depending on CR, treatment was given for four or six cycles.

Twenty-six patients were treatment na < ve and 13 were pre-treated. Twelve patients had progressive Binet stage A, 16 stage B and 11 stage C disease. The overall response rate (ORR) was 100%,

with 75% achieving CR. Neutropenia was the major toxicity in 71/187 (38%) of the cycles. There were five deaths, two from infection and three from progressive disease. Twenty-six of 31 patients have maintained their post-treatment disease Cytoskeletal Signaling inhibitor status for a median of 17 months (2-41).

We conclude that FCR is a feasible, well-tolerated and effective treatment for patients with CLL.”
“Background: Several studies have found that living near major roadways is associated with an increase in respiratory illness but few studies have measured the volume and type of traffic.

Objective: We investigated the relation between traffic volume and respiratory health of 2328 children 9 to 11 years old in the city of Windsor, Canada.

Methods: We identified the roadways within a 200 meter radius of the child’s neighborhood using the latitude and longitude of the residential postal code.

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