05). I-FABP levels [(75.21 ± 34.22) ng/ml] and Fc levels [(463.27 ± 114.82) ug/g] in IBD + IBS group were significantly higher than those in IBD-IBS group [I-FABP (33.27 ± 14.03) ng/ml, Fc (181.25 ± 53.17) ug/g], IBS group[I-FABP (25.61 ± 10.31) ng/ml, Fc (131.92 ± 101.12) ug/g], and controls[I-FABP (11.33 ± 7.13) ng/ml, Fc (102.61 ± 85.42) ug/g] (p < 0.01). Furthermore, I-FABP levels in IBD-IBS
group were higher than those in IBS group and controls (p < 0.05). However, there were no differences on Fc levels among IBD-IBS, IBS and controls group (p > 0.05). Conclusion: IBS-like symptoms are common in IBD patients in buy Inhibitor Library long-standing remission, which attributed to occult inflammation rather than coexistent IBS. Key Word(s): 1. ulcerative colitis; 2. IBS; 3. I-FABP; 4. calprotectin; Presenting Author:
ZHU ZHENHUA Additional Authors: ZENG ZHIRONG, PENG XIABIAO, PENG LIN, HAO YUANTAO, QIAN JIAMING, NG SIEW CHIEN, CHEN MINHU, HU PINJIN Corresponding Author: CHEN MINHU, HU PINJIN Affiliations: sun yat-sen university; Zhongshan people’s hospital; Zhongshan hospital of traditional Chinese medicine; Peking Union Medical College Hospital; The Chinese University of Hong Kong Objective: The incidence of inflammatory bowel disease (IBD) is increasing in China with urbanization and socioeconomic development. There is however a lack of prospective, Adriamycin mw population-based epidemiology study on IBD in China. The aim of the study is to define the incidence and clinical characteristics of MCE IBD in a developed region ofGuangdong Province in China. Methods: A prospective, population-based incidence study was conducted from July 2011 to June 2012 in Zhongshan, Guangdong, China. All newly diagnosed IBD cases inZhongshan were included. Results: In total, 48 new cases of IBD (17 Crohn’s disease [CD]; 31 ulcerative colitis [UC])
were identified over a 1-year period from July 2011. Age-standardized incidence rates for IBD, UC, and CD were 3.14, 2.05, and 1.09 per 100 000 persons, respectively. The median age of UC was 38, and that of CD was 25. Terminal ileum involvement only (L1), isolated colonic disease (L2), and ileocolonic disease (L3) were reported in 24%, 6%, and 71% of patients with CD, respectively. Twenty-four percent of patients had coexisting upper gastrointestinal disease (L4). Inflammatory (B1), stricturing (B2), and penetrating (B3) behavior were seen in 65%, 24%, and 12% of CD patients, respectively. Fifty-nine percent of CD and 26% of UC patients had extra-intestinal manifestations. Conclusion: This is the first prospective, population-based IBD epidemiological study in a developed region of China. The incidence of IBD is similar to that in Japan and HongKong but lower than that in South Korea and Western countries. Key Word(s): 1. China; 2. IBD; 3. incidence; Table 1.