7 mu g/kg) at the same doses as those that decreased the phenylephrine induced increase in intravesical ureteral pressure (ID(50) 225.1 mu g/kg). Silodosin uroselectivity was markedly higher than that of naftopidil (58.6 vs 1.3).
Conclusions: Results suggest that a selective alpha(1A)-adrenoceptor antagonist such as silodosin may facilitate distal ureteral stone passage
at nonhypotensive doses.”
“A frequency associated deterioration of the hand grip (GF; normal component of force acting at the digits-object contact area) and load force (LF; the tangential component) coordination has been demonstrated in a variety of repetitive manipulation tasks. However, it remains unknown whether the effect LY294002 concentration Raf inhibitor originates from the task frequency per se, or from the rate of LF change (a prediction that could be derived from the minimum jerk hypothesis) which increases with both LF frequency and LF range. The aim of the study was to discern between the effects of LF frequency and LF
range (which affects only the rate of LF) in static manipulation tasks. Subjects (N= 15) exerted a sinusoidal LF pattern against an externally fixed instrumented handle at 5 different LF frequencies (0.67-3.33 Hz) and ranges (6-30 N). The results revealed weak and mainly non-significant effects of both LF range and frequency on GF scaling (GF/LF ratio). However, both GF-LF coupling (assessed by correlation coefficients) and GF modulation (change in GF relative to LF variation) demonstrated a prominent decrease associated with LF frequency, but not with LF range. The observed findings were interpreted by switching between hypothetical synergies of GF and LF producing muscles separately employed in the phases of the increasing and decreasing forces. From the practical aspect, however, the results suggest that the frequency, but not the LF Selleck AZD2014 range should be taken into account when designing rhythmic
manipulation tasks, developing standard tests of hand function based on GF-LF coordination, or comparing the data from different studies. (C) 2010 Elsevier Ireland Ltd. All rights reserved.”
“Purpose: To our knowledge the mechanism of neurodegeneration in the overactive bladder remains unknown. We examined mitochondrial integrity and searched for markers of oxidative neural injury in the ischemic overactive bladder.
Materials and Methods: A rabbit model of overactive bladder was developed by inducing moderate pelvic ischemia. After 16 weeks cystometrograms and blood flow recordings from overactive bladders were compared with those in age matched controls. Bladder tissues were processed to assess oxidative products, oxidative stress sensitive genes and nerve fiber density using enzyme immunoassay, quantitative real-time polymerase chain reaction and immunohistochemical staining, respectively. Tissue ultrastructure was examined by transmission electron microscopy.