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than the acid forms in human skeletal muscle cells in vitro. Eur J Pharm Sci 2008, 33:317–325.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions MY and MT carried out cell viability assay, caspase-3 activity assay, statical analysis, and drafted the manuscript. TS, TI, MI, and YY carried out western bolotting analysis. TS, TI, and MI contributed to statistical analyses. SN designed the experiments and revised the manuscript. All authors read and approved the final manuscript.”
“Background Laryngeal carcinoma is a common head and neck malignancy with high incidence as it accounts for approximately 2.4% of new malignancies Selleckchem Doxorubicin worldwide every year [1, 2]. Despite recent advances in cancer treatment, the prognosis for patients with laryngeal carcinoma especially at advanced stage remains poor. Therefore, it is essential to investigate the mechanism involved in the development and progression of laryngeal carcinoma. MicroRNAs (miRNAs) are a new class of small, non-coding RNAs and regulate gene expression by binding to the 3′-untranslated regions (3′UTRs) of specific mRNAs. miRNAs could function as oncogenic miRNAs or tumor suppressor miRNAs, playing crucial roles in the development and progression of carcer [3, 4]. Recent studies have indicated that frequent deregulation of miRNA in laryngeal carcinoma [5, 6].