Godula-Stuglik et al. [24] showed that full-term neonates with sepsis during the first week of life have a significant increase
in CD3+. In the present study, in partial agreement, increased CD3+ was found in neonates with sepsis, but as their CD4+ and CD8+ levels were also raised, the ratios remained unchanged. NK cells are a part of the innate immune system that is very important during the neonatal period. The neonatal defence is initially dependent on this type of immunity, as antigen-specific immunity develops later in life, and the NK cell count is higher in neonates than in older children and adults [25, 26]. Severe sepsis https://www.selleckchem.com/products/17-AAG(Geldanamycin).html in adults has been related with increases in NK cells, providing a survival benefit for the patient with sepsis at percentages >20% [11]. The neonates with sepsis in the present study had elevated numbers of NK cells, despite the fact that the total lymphocyte counts did not differ among the three groups. An increase in NK cells was also observed in neonates with suspected infection.
Upregulation of many surface activation markers on peripheral blood-derived T cells, monocytes and NK cells was recently found in neonates with sepsis [27], and the upregulation of CD69 on NK cells was shown to be a sensitive marker of neonatal infection. It has been speculated that there may be a protective effect of increased NK cells for the infected host [11]. Increased B cells selleck products were also found in the neonates with possible
or documented infection in the present study. Studies in adults have shown either decreased or increased B cell numbers in patients with sepsis; the former may be a phenomenon occurring later in the course of the sepsis [11, 12]. Whether the changes described in the lymphocyte ADAM7 subsets in the full-term neonates with sepsis represent the absence of a normal maturation process, pathological events or immaturity is still not clear. IgM, in contrast to IgG, does not cross the placental barrier, and its elevation implies the neonate’s own post-natal production as a reaction to infective agents. IgM was elevated in the neonates with sepsis at the second time period of the study. Other researchers also have found elevation of IgM in neonates with sepsis and have proposed that it may be used, coupled with IL-6, as an early detector of neonatal sepsis [28]. In that study, IgM levels were higher in sepsis and moderately elevated in suspected infection compared with healthy neonates as observed in the present study at the second study period. The IgG levels were repeatedly lower in the possibly infected and even lower in the neonates with sepsis in this study compared with the control subjects. A causative could be speculated between low IgG levels and sepsis, with the reservation that biochemical IgG values were measured rather than functional parameters that could establish a functional deficit.