However, a limitation of this study was that our patients had INR values on the lower end of spectrum in both cohorts and inter-laboratory variability of INR has been shown to be greater with higher mean INRs (Am J Transplant 2007, 7:1624-280) Disclosures: Neeral L. Shah – Grant/Research Support: Boehringer Ingelheim RGFP966 concentration Stephen H. Caldwell – Advisory Committees
or Review Panels: Vital Therapy; Consulting: Wellstat diagnostics; Grant/Research Support: Genfit, Gilead Sciences Patrick G. Northup – Grant/Research Support: Hemosonics, Bristol Meyer Squibb Curtis K. Argo – Consulting: Wellstat Diagnostics; Independent Contractor: Genentech/Roche The following people have nothing to disclose: Dennis Kumral, Nicolas M. Intagliata “
“Genetic variation near the IL28B gene and substitution of amino acid (aa) 70 and 91 in the core
region of hepatitis C virus (HCV) genotype 1b can predict the response to pegylated interferon (PEG-IFN)/ribavirin combination therapy, but its impact on triple therapy of telaprevir/PEG-IFN/ribavirin is not clear. The aims of this study were to investigate the predictive factors of sustained virological response to a 12-week or 24-week regimen of triple therapy in 72 of 81 Japanese adults infected with HCV genotype 1. Overall, sustained virological response and end-of-treatment response were achieved by 61% and 89%, respectively. Especially, the sustained virological response was achieved by 45% and 67% in the 12- and 24-week regimens, respectively. Multivariate analysis identified rs8099917 near the IL28B gene (genotype TT) and substitution at aa 70 (Arg70)
as significant determinants of sustained virological response. Prediction of response MK-1775 purchase to therapy based on a combination of these factors had high sensitivity, specificity, and positive and negative predictive values. The efficacy of triple therapy selleck was high in the patients with genotype TT, who accomplished sustained virological response (84%), irrespective of substitution of core aa 70. In the patients having genotype non-TT, those of Arg70 gained high sustained virological response (50%), and sustained virological response (12%) was the worst in patients who possessed both genotype non-TT and Gln70(His70). Conclusion: This study identified genetic variation near the IL28B gene and aa substitution of the core region as predictors of sustained virological response to a triple therapy of telaprevir/PEG-IFN/ribavirin in Japanese patients infected with HCV genotype 1b. (HEPATOLOGY 2010) Hepatitis C virus (HCV) usually causes chronic infection that can result in chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC).1, 2 At present, treatments based on interferon (IFN), in combination with ribavirin, are the mainstay for combating HCV infection. In Japan, HCV genotype 1b (HCV-1b) in high viral loads (>100 KIU/mL) accounts for more than 70% of HCV infections, making it difficult to treat patients with chronic hepatitis C.