In addition,

In addition, Erlotinib price the ��PCT D2�CD3 was found to be independently associated with antibiotic appropriateness by logistic regression (Table (Table3).3). Finally, PCT elevation by D4 was significantly lower in patients who had received appropriate antibiotics than in those who had not (P = 0.03).Table 2Procalcitonin changes at various time points in patients with bacterial sepsis according to antibiotic therapyTable 3Factors predictive of the appropriateness of first-line empirical antibiotic therapy in patients with bacterial sepsisIn contrast, no difference was found from D1 to D4 if other potential relevant clinical or biological endpoints were considered (that is, SOFA score, platelet count, blood lactate concentration, mean arterial pressure, PaO2/FiO2, creatininemia, C-reactive protein), as detailed in Table Table44.

Table 4Time course to endpoints other than procalcitonin in bacterial sepsis patients according to antibiotic therapySurvival analysisThe crude ICU 28 day-mortality was 24.4% in the study population. Age, SAPS II value on admission and SOFA score on the first day of sepsis were found to be associated with an unfavorable outcome (Table (Table1).1). Septic shock at the onset of sepsis was also more frequent in nonsurvivors than survivors (63.3% vs. 32.8%, respectively; P < 0.01). In addition, these nonsurviving patients were more likely to present with pneumonia and to suffer from Gram-negative infection than were survivors. Among biological and physiological variables, the serum lactates and the platelet count were found to be significantly different between survivors and nonsurvivors.

In contrast, neither the PCT baseline value (that is, the D1 value) nor the D2 value was associated with death in the study population despite a trend toward greater values in the nonsurvivors (Table (Table5).5). PCT was found to be significantly higher, however, in nonsurvivors than in survivors by D3 and D4. The ��PCT D2�CD3 value was calculated for only 147 patients because of missing data and because of the death of some patients within this period. ��PCT D2�CD3 was found to be an independent predictor of a bad outcome. In addition, a ��PCT D2�CD3 lower than -30% was associated with death in our study (log-rank test: P = 0.04) (Figure (Figure1).1). ��PCT D2�CD3 was also found to be an independent predictor of a bad outcome in our multivariate analysis (odds ratio = 2.94; 95% confidence interval = 1.22 to 7.09; P = 0.02) (Table (Table66).Figure 1Kaplan�CMeier estimated survival after the onset of bacterial sepsis. Kaplan�CMeier Anacetrapib estimated survival in the intensive care unit after the onset of bacterial sepsis in 147 patients with bacterial sepsis according to the procalcitonin variation …

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