ITF2357 Givinostat S-Mre11 complex mammal Rad50-NBS1 proteins

Ion of p53 by ATM in response to DNA-Sch The. Science 1998, 281:1674 �. 9th Canman CE, Wolff AC, Chen CY, Fornace AJ Jr, Kastan MB. P53-dependent Controlled Independent G1 cell The bike path and ataxia-telangiectasia. Cancer Res 1994; 54:5054 �. 10th Canman CE, Lim DS, Cimprich KA, et al. ATM kinase activation by Givinostat ITF2357 ionizing radiation and phosphorylation of p53. Science 1998, 281:1677 �. 11th Matsuoka S, Rotman G, Ogawa, A., et al. Ataxia telangiectasia mutated Chk2 phosphorylated in vivo and in vitro. Proc Natl Acad Sci U S A 2000; 97:10389 � 4. 12th Maya R, M Balass, ST Kim et al. ATM-dependent phosphorylation of Mdm2 on serine Independent 395: R in the activation of p53 by DNA-Sch ending. Genes Dev 2001, 15:1067 7 �. 13th Kim ST, Xu B, Kastan MB.
The participation of the carbon Sin protein, SMC1, in ATM-dependent Independent responses and Panobinostat independent Stranded DNA-Sch To. Genes Dev 2002; 16:560 � 0th 14th Lim DS, Kim ST, Xu B, et al. ATM phosphorylates checkpoint p95/nbs1 way into the S phase, Nature 2000, 404:613 �. 15th Taniguchi T, Garcia-Higuera I, Xu B, et al. Convergence of the Fanconi On Ataxia telangiectasia signaling pathways and chemistry. Cell 2002; 109:459 � second 16th Xu B, O � �D onnell AH, Kim ST, Kastan MB. Phosphorylation of serine 1387 in BRCA1 is specifically designed for the ATM-mediated S phase checkpoint after ionizing radiation is required. Cancer Res 2002; 62:4588 one �. 17th Bao S, Tibbetts RS, Brumbaugh KM, et al. ATR / ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 2001, 411:969 � 4th 18th Petrini JH.
The S-Mre11 complex mammal Rad50-NBS1 proteins: integration of functions in the cellular DNA-Ren Sch the reaction. Am J Hum Genet 1999; 64:1264 �. 19th Scully R, Livingston DM In search of tumor-suppressor functions of BRCA1 and BRCA2. Nature 2000; 408:429 � second 20th Choudhury A, Cuddihy A, Bristow RG. Radiation and new molecular agents part I: The targeting of checkpoints, repair of DNA ATMATR, and the proteasome. Semin Radiat Oncol 2006; 04.51 clock �. 21st Eastman checkpoints A. The cell cycle and its impact on therapeutic strategies against cancer. J Cell Biochem 2004; 91:223 a �. 22nd Sarkaria, JN, Eshleman JS. ATM as a target for novel radiosensitizers. Semin Radiat Oncol 2001; 11:316 7 �. 23rd Kastan M. Ataxia-telangiectasia – broad implications for a rare disease.
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The loss of the ARF tumor suppressor versa premature replicative arrest but not radiation hypersensitivity, the disabled from ATM function. Cancer Res 1999; 59:2464 �. 28th RT Williams, The Best W, Sherr CJ. Cytokine-dependent Independent imatinib resistance in mouse BCR-ABL +, Arf-null lymphoblastic leukemia Chemistry. Genes Dev 2007; 21:2283 �. 29th Kim ST, Lim DS, Canman CE, Kastan MB. Substrate specificity Th and identification of substrates of Mutma Lay members of the ATM kinase family. J Biol Chem 1999; 274:37538 � third 30th Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. Phosphorylation of SMC1 is a critical event in the downstream signaling pathway ATM-NBS1-BRCA1. Genes Dev 2004; 18:1423 8 �. 31st Xu B, Kim ST, Lim DS, Kastan MB. Two different molecular weight G / M

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