Not all efforts in this field are directed towards mimicking biologically relevant metal ion sites, with potential applications extending from energy transfer to DNA binding. The use of artificial and miniature
protein scaffolds allows the inorganic chemist to answer challenging questions about metal biochemistry, the importance of the protein matrix, and ultimately be able to design new metalloproteins de novo capable of performing desired functions not necessarily in the repertoire of biology. The examples discussed herein are making significant progress to these goals and importantly demonstrate Ion Channel Ligand Library mouse that complex protein architectures are not a requirement for tuning the metal ion properties. Papers of particular interest, published within the period of review, have been highlighted as: • of special interest Support from the University of Birmingham, The Royal Society, EU COST Action CM1105 and the EPSRC are gratefully acknowledged.
Ku-0059436 manufacturer “
“Current Opinion in Chemical Biology 2013, 17:1039 Available online 15th November 2013 1367-5931/$ – see front matter, © 2013 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.cbpa.2013.10.025 It has come to our attention that when referring to multi-enzyme systems for the synthesis of sugar phosphates, we have omitted to mention the work of Fessner and collaborators’ “Multi-enzymatic cascade synthesis of d-fructose 6-phosphate and deoxy analogs as substrates for high-throughput aldolase screening”, Catal. Sci. Technol., 2012, 2, 1596–1601. We would like to apologize for this inexcusable
mistake. Astemizole Likewise, in the introduction of our review we have omitted mention some of the pioneering work in the field of Enzyme catalysed tandem reactions. These omissions are due to an excessive zeal to follow the instructions for authors of Current Opinion in Chemical Biology, which specify that reviews should be a concise overview of the field at the time of writing outlining the most important developments in the past 2 years. Our work was never intended to be a comprehensive review of the field but our personal vision of what were the most important advances in the field of Enzyme catalysed tandem reactions in recent years. Therefore, we apologize to all the authors who feel that their work has been misrepresented. “
“Suresh K. Mukherji Jonathan R. Dillman and Ethan A. Smith Christopher P. Keup, Felicia Ratnaraj, Pooja R. Chopra, Charles A. Lawrence, and Lisa H. Lowe Hepatic neoplasms constitute approximately 5% to 6% of all pediatric intra-abdominal masses, most of which are malignant.