One major consideration appears to have been the costs of the vaccine to countries.
Of concern OICR-9429 order is that Asian countries have been slow to introduce rotavirus vaccines despite having robust data that could inform the decision-making process. Although decisions on new vaccine introduction are very complex and vary by country and region, economic evaluations are often pivotal once vaccine efficacy and safety has been established, and disease burden documented and communicated. Unfortunately, with private sector list prices of vaccines often used in economic evaluations, rather than a potential public health sector pricing structure, policy-makers may defer decisions on rotavirus vaccine introduction based on the belief that “”the vaccine price is too high,”" even though this might be based on erroneous data. The Pan American Health Organization’s Revolving Fund provides one example of how vaccine price can be made more competitive and transparent
through a regional tendering process. Other mechanisms, such as tiered pricing and UNICEF procurement, also exist that could help Asian and other countries move forward more quickly with rotavirus vaccine introduction.”
“OBJECTIVE: We hypothesized that differential mRNA transcription between the sexes may be linked to the 9:1 female-to-male gender-related relative risk for the development of Sjogren’s syndrome (SS), an autoimmune disease that leads to inflammation and dysfunction in the lachrymal and salivary glands.
SUBJECTS Microtubule Associat inhibitor AND METHODS: RNA from minor salivary glands was collected from nine healthy volunteers VX770 (four men and five women) and analyzed using the Agilent 4 x 44K human
microarray platform. Differential expression was confirmed by qRT-PCR.
RESULTS: Comparison of the transcriptome of minor salivary glands from normal male and female volunteers with that of salivary glands and secretory epithelia identified a number of gender, species, and tissue-specific gene expression patterns. These differences include, but are not limited to, a diverse set of genes involved in immune modulation, chemotactic control, inhibition of complement, metabolism, and neurogenesis.
CONCLUSION: Analysis of these changes provides insight into the protective and predisposing molecular factors that may be involved in the development of Sjogren’s syndrome. Some of the gene changes observed in this study correlate with previously observed sexual dimorphisms in salivary gland function and also illustrate several new targets for further investigation. Oral Diseases (2011) 17, 653-661″
“Background: The CQ Index for the elderly, a quality-of-care questionnaire administered by conducting interviews, is used to assess clients’ experiences in Dutch nursing homes and homes for the elderly.