Table 4 Standard over-the-counter (OTC) dose for paracetamol PF-02341066 mouse and ibuprofen Paracetamol Ibuprofen Age 2–3 months: 60 mg, with a further 60 mg after 4–6 hours if necessary (maximum of two doses) [89] Age 3–5 months: 50 mg three times a day (maximum of three doses in 24 hours, do not use for more than 24 hours) Age 3–6 months: 60 mg every 4–6 hours (maximum of four doses in 24 hours) Age 6 months to
1 year: 50 mg three to four times a day Age 6–24 months: 120 mg every 4–6 hours (maximum of four doses in 24 hours) Age 1–4 years: 100 mg three times a day Age 2–4 years: 180 mg every 4–6 hours (maximum of four doses in 24 hours) Age 4–7 years: 150 mg three times a day Age 4–6 years: 240 mg every 4–6 hours (maximum of four doses in 24 hours) Age 7–10 years: 200 mg three times a day Age 6–8 years: 250 mg every 4–6 hours (maximum of four doses in 24 hours) Age 10–12 years: 300 mg three times a day Age 8–10 years: 375 mg every 4–6 hours (maximum of four doses in
24 hours) Age 12–16 years: 200 SYN-117 solubility dmso to 400 mg three to four times a day Age 10–16 years: 500 mg every 4–6 hours (maximum of four doses in 24 hours) Source: [90] Source: [90] Higher doses and different routes of administration may be used for pediatric fever in hospitalized patients Reports of complications following ibuprofen overdose, particularly in children, are rare. The vast JPH203 order majority of individuals who overdose on ibuprofen alone have no, or only mild, symptoms however [74]. Fatal overdose in adults is extremely rare and is generally related to complicating factors such as the presence of other drugs. Cases of symptomatic overdose in children have been reported following ingestion of over 440 mg/kg [75], but in general the risk of serious complications following ibuprofen overdose is low [76]. 3.4.5 Other An increased risk of severe cutaneous complications in patients with varicella or herpes zoster has been reported for NSAIDs but
not for paracetamol [77]. Consequently, it has been recommended that fever and pain associated with varicella or herpes zoster infection should be treated with paracetamol, not an NSAID [77]. 3.4.6 Safety: Summary Specific safety issues that are often cited for ibuprofen and paracetamol may be a consideration for specific patient populations, but for the average child with symptoms of distress related to low-risk fever (that is, in the absence of underlying health issues) they are of less concern. Ibuprofen and paracetamol have similar safety and tolerability profiles when short-term OTC doses are used. 3.5 Combination Therapy The use of combination therapy with either alternating or simultaneous use of ibuprofen and paracetamol in feverish children is controversial.