That is, carrying the GA and AA genotypes may increase ovarian
cancer susceptibility by 1.64-fold (95% CI: 1.37-1.95; P = 0.004) and 1.81-fold (95% CI: 1.56-2.14; P = 0.004) compared with the GG genotype respectively. The data in Table 2 indicated that no associations of p63 rs873330 T > C and p73 rs4648551 G > A with ovarian cancer pathogenesis were found. Akt inhibitor In summary, we determined that the rs6695978 A allele may be the at-risk allele for ovarian cancer, suggesting that carriers of the A allele may be more susceptible to ovarian cancer among Chinese women. Table 2 Logistic regression analyses on associations between p63 rs873330, p73 rs4648551, rs6695978 and risk of ovarian cancer Gene and SNP Genotype of SNP No. of subjects (%) Adjusteda Controls Cases P OR (95 % CI) p63 rs873330 T > C TT 182 (56.7) 160 (52.0) 0.142 1.00 (ref) TC 118 (36.8) 122 (39.6) 1.15 (0.88-1.52) CC 21 (6.5) 26 (8.4) 1.21 (0.78-1.89) T allele 482 (75.1) 442 (71.8) MM-102 in vivo C allele 160 (24.9) 174 (28.2) 0.098 1.16 (0.79-1.68) p73 rs4648551 G > A GG 316 (97.5) 296 (96.1) 0.936 1.00 (ref) GA 8 (2.5) 10 (3.3) 1.05 (0.91-1.22) AA 0 (0.0) 2 (0.6) G allele 640 (98.8) 602 (97.7) A allele 8 (1.2) 14 (2.3) 0.558 1.41 (0.99-1.93) rs6695978 G > A GG 240 (74.1) 198 (64.3) 0.004 1.00 (ref) GA 73 (22.5) 94 (30.5) 1.64 (1.37-1.95) AA 11 (3.4) 16 (5.2) 1.81 (1.56-2.14) G allele 553 (85.3) 490 (79.5) A allele 95 (14.7)
126 (20.5) 0.003 1.55 (1.07-2.19) a. OR and 95% CI represent odds ratios and 95% confidence intervals from logistic regression analysis, adjusted for age, BMI, number liveborn, oral contraceptive use, cigarette smoking, ovarian
cancer family history. All statistical tests were two-sided with a significance level of P ≤ 0.05. The p73 rs6695978 G > A SNP was positively associated with known clinicopathological variables. Considering that none of the investigated SNPs except the p73 rs6695978 G > A had shown an association between the case group and the control group, we merely listed the data between the rs6695978 G > A genotype frequencies and the clinicopathological characteristics, including age at diagnosis, tumor histology, degree of differentiation, Thiamet G clinical stage , tumor behavior, lymph node status, estrogen receptor (ER) and progesterone receptor (PR) status (Table 3). The results from the logistic regression models revealed that the A allele was positively associated with the occurrence of mucinous ovarian cancer (OR = 3.48; 95% CI:1.15-6.83; P = 0.001), low degree of selleck differentiation (OR = 1.87; 95% CI:1.03-3.47; P = 0.003), lymph node metastasis (OR = 1.69; 95% CI: 1.14-2.75; P = 0.010) and ER positive (OR = 2.72; 95% CI: 1.38-4.81; P = 0.002), which can be used to predict disease prognosis and treatment outcomes.