The selleck inhibitor authors thank Naoko Kawahara,

Takashi Nakamura, and Keiko Takeshita for their technical assistance. Additional Supporting Information may be found in the online version of this article. “
“Hair disorders that have been described in association with pegylated interferon–ribavirin combination treatment include canities, hypertrichosis, telogen effluvium, and the most common cutaneous side-effect by far, alopecia. Alopecia is a heterogeneous disease characterized by hair loss on the scalp or any hair-bearing surface with a wide range of clinical presentations, from a single patch of hair loss to complete loss of hair on the entire body (alopecia universalis). Although some cases of reversible alopecia universalis associated with pegylated interferon–ribavirin combination therapy have been reported in the published work, irreversible alopecia universalis

has not yet been reported in relation to pegylated interferon and ribavirin combination treatment. For the first time, we report a case of irreversible alopecia Sotrastaurin in vivo universalis during pegylated interferon–ribavirin combination therapy in a man infected with hepatitis C virus in the absence of clinical or biochemical evidence of immunological disorders or thyroid dysfunction at any time before, during or after antiviral therapy. “
” The Journal of Gastroenterology and Hepatology (JGH), an official journal of the Asian Pacific Association of Gastroenterology (APAGE) and an affiliated journal of several national gastroenterology and liver associations, will soon have a new Editor-in-Chief. From January 2013 Professor Mamoru Watanabe takes on this important leadership role, after completion of Professor Geoff Farrell’s 6-year term. Dr Watanabe is a Professor and Chairman in the Department of Gastroenterology and Hepatology, Department of Endoscopy, Tokyo Medical and

Dental University. selleck products He is also the Director in the Advanced Clinical Center for Inflammatory Bowel Disease in this major teaching and academic Hospital. I have known Dr Watanabe both personally and professionally during the past 30 years. He is a best friend of mine. We both graduated from the same School of Medicine, Keio University in Tokyo and worked in the same Department of Internal Medicine in Keio for 20 years. He was a 3-year junior to me, and I was his first supervisor for his clinical training in the Department of Gastroenterology in Keio. On the basis of this longstanding interaction, I hold him in the highest esteem, both as a physician and scientist, and know he will continue to make major leadership contributions to both clinical and basic investigations in gastroenterology. It has been more than 25 years since JGH was born from the Asia-Pacific Region.

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