TK was involved in conception and design, interpretation of data, revising the manuscript for content, and supervision. All authors have approved the final version of the manuscript and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. Funding:
www.selleckchem.com/products/CHIR-258.html The 3C study is conducted under a partnership agreement between the Institut National de la Santé et de la Recherche Médicale (INSERM), the Victor Segalen–Bordeaux II University and the Sanofi-Synthélabo Company. The Foundation pour la Recherche Médicale funded the preparation and initiation of the study. The 3C Study is also supported by the Caisse Nationale Maladie des Travailleurs Salariés, Direction Générale de la Santé, Haute Autorité de la Santé, Institut National de Prévention et d’Education pour la Santé, Conseils Régionaux of Bourgogne, Fondation
de France, Ministry of Research-INSERM Program “Cohortes et collections de données biologiques,” Mutuelle Générale de l’Education Nationale, Institut de la Longévité, Conseil Général de la Côte d’or. PMR was supported by the Rose Traveling Fellowship Program in Chronic Disease Epidemiology and Biostatistics from the Harvard School of Public Health. Competing interests: PMR has received within the past 2 years funding from a training grant from the National Institute of Aging and from the Rose Traveling Fellowship Program in Chronic Disease Epidemiology and Biostatistics from the Harvard School of Public Health. CT has received fees from the Fondation Plan Alzheimer, the Fondation de Recherche sur l’Hypertension Artérielle, and ABBOTT for participating in scientific committees. He has also received investigator-initiated research funding from the French National Research Agency (ANR) and the Fondation Plan Alzheimer for the 3C study. TK has received within the past 2 years
investigator-initiated research funding from the French National Research Agency, and the US National Institutes of Health. Further, he has received honoraria from the American Academy of Neurology for educational lectures Brefeldin_A and from the BMJ and Cephalalgia for editorial services. AE has received within the past 2 years investigator-initiated research funding unrelated to this project from the French National Research Agency, EU Joint Programme—Neurodegenerative Disease Research (JPND), the French Agency for Drug Security (ANSM), and the French Institute for Research in Public Health (IRESP). CD has received honoraria from the American Academy of Neurology for educational lectures and from Eisai, Inc for providing methodological expertise. Ethics approval: The Ethical Committee of the University Hospital of Kremlin-Bicêtre approved the methods and procedures of the 3C study. Provenance and peer review: Not commissioned; externally peer reviewed. Data sharing statement: No additional data are available.