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Chromatin Immunpr Zipitation Voriconazole Vfend independent Independent sequences Age data derived AR binding site in line LNCaP model basis. Data overlapping ARBS 60% between the two studies. To the ARBS Verm Best term assets, We used data from the methylation of histone two independent Independent data records Tze. The other data set contained data is used to chip monomethylated H4K3 and all other data Changes in H3K4me2 signal resulting destabilization of the nucleosome stability t score for nucleosomes. Both histone was shown to be associated with active zones enhancer. Approximately half of the H Of the 128 genes contain potentially active Fl Chemical enhancers with ARBS. Together, reduced from the 128 genes that were twice expression taken after endocrine treatment, 24 genes were stimulation of DHT in the model cell lines induced ARBSs showed in the N Height of the TSS independent than two Independent studies, or even to the TSS showed ARBS closing s for trials and content potentially active enhancer. The differential expression of six of the 24 genes by qRT-PCR was best CONFIRMS. As n To search results, we examined the expression of three of these androgen-regulated genes directly to the protein level. We immungef Rbt samples tested with antique Rpern against TMEFF2, TPD52 and NEDD4L and plenty of F Staining in all specimens with antique Rpern TPD52 and NEDD4L, which show a high expression was observed at the protein level in prostate cancer. However, k Nnten significant differences between treatment groups are not evaluated. TMEFF2 F Staining, however, was significantly lower both bicalutamide and goserelin-treated samples compared to control samples. In addition, we have determined whether the genes whose expression decreased after endocrine therapy in CRPC would be reactivated. We ma S expression of four selectedgenes that TMEFF2 that DHCR24, the TPD52 and NEDD4L in an independent Ngigen group of benign prostatic hyperplasia, prostate cancer and previously untreated samples by qRT PCR CRPC. We found that DHCR24 and TPD52 were significantly in samples of prostate cancer compared to NEDD4L BPH samples and overexpressed TMEFF2 was a trend toward significance. The expression of TPD52 and NEDD4L has also been obtained Ht fa Is significant in CRPC samples compared to samples of BPH and DHCR24 and TMEFF2 was a trend to significance. Nally, we tested TMPRSS: ERG fusion in the test samples with IHC and fish. Of the 25 samples, the cancerous space for the test 15 samples were positive for the fusion gene. Cases due to the small number of F, We combined the bicalutamide and goserelin groups treated endocrine in a pooled sample. First, we have r evaluated The ERG and AR in contr The endocrine and treated groups. In the control group we found significant expression of h Ago at 869 genes in Fusionsf Cases of positive and negative event of a merger. The treatment, otherwise, a reduction in the expression of genes in 601 F Cases but only 69 genes in the case F F. were Interestingly, the H Half of the genes that were for F vs. F in the case of the controlled group ht obtained usual, the people who were after the treatment in case of F. downregulates To determine whether the differentially expressed genes are direct targets.