We aimed to find (1) suppressed brain responses in the subtraction analysis UNREL > REL, (2) enhanced brain responses in the subtraction analysis of REL > UNREL, and (3) communalities between related distractors in comparison to the unrelated distractor in conjunction analyses. In order to eliminate deactivations of the subtrahend becoming significant because of the subtraction, contrasts were inclusively masked by the minuend with P = 0.05 uncorrected (e.g., Inhibitors,research,lifescience,medical Vohn et al. 2007). Activation maxima reaching an α-threshold of 0.05 corrected
for multiple comparisons with the false click here discovery rate (FDR) method (Genovese et al. 2002) and at least 30 contiguous voxels were rendered onto the lateral Inhibitors,research,lifescience,medical and/or medial surface of a standard brain and presented in a table. An α-threshold of 0.001 (uncorrected for multiple comparisons)
was considered for the subtraction analyses of related > unrelated distractors (for figure and table, ≥5 voxels) and the complex conjunction analyses (for the table, ≥5 voxels). An appropriate identification of resulting brain structures was ascertained by using WFU PickAtlas (http://www.rad.wfubmc.edu/fmri) Inhibitors,research,lifescience,medical and Talairach daemon client (http://www.talairach.org), complemented by information about the extent of activation clusters gained from MNISpace (http://www.ihb.spb.ru/~pet_lab/MSU/MSUMain.html). Results A full consideration of the behavioral data and the neural
responses for comparisons of related distractors Inhibitors,research,lifescience,medical can be found in Abel et al. (2009a) (see also Figs. S1, ,2;2; Table 1). Figure 3 presents repetition suppressions as given in the comparison of the unrelated distractor condition to related conditions (see also Table 2). We report peaks and extension of activations. Signal decreases for the phonological distractor condition (Fig. 3A) comprised a large cluster with peaks in left lingual gyrus (LG) (Brodmann area [BA] 18), right middle occipital gyrus, right subgyral Inhibitors,research,lifescience,medical frontal area (extending to medial frontal gyrus), as well as left SMA/ACC (BA 32). SMA activation mainly involved pre-SMA, but also extended to SMA-proper. Moreover, a peak in left parahippocampal gyrus (BA 20) was observed. All these areas were deactivated bilaterally and extended to bilateral fusiform gyrus (FG), inferior occipital gyrus, cuneus and precuneus, pre- and postcentral gyrus, Dichloromethane dehalogenase thalamus, anterior insula, cerebellum, and brainstem. Figure 3 Repetition suppression: areas of significant brain activation (contrasts thresholded at false discovery rate [FDR]P < 0.05 [at least 30 voxels] and masked by the minuend at P < 0.05 uncorrected) when subtracting a related distractor condition … Table 2 Response suppressions: decreases in brain activity for the related distractor condition compared to the unrelated condition For the associative distractor condition (Fig.