Monthly Archives: May 2017

03, p = 0.6 for velocity and r2 = 0.02, p > 0.72 for acceleration). Correlations of firing rates between different arms indicate that the population of mPFC single units is capable of representing anxiety-related task components. However, such correlations do not … Continue reading →

15 or 1 c/deg), TF (1 or 4 Hz) and mean luminance level (19 or 36 cd/m2) so that the only difference between these two types of gratings were their color contents (Lu and Roe, 2008). For each stimulus condition, a percentage … Continue reading →

In contrast, positive peaks in scalp EEG tightly corresponded to negative peaks of depth EEG and to ON periods with rigorous spiking, in accordance with a depolarized up state. We set out to examine quantitatively the relationship between sleep slow … Continue reading →

, 1989, Hassenstein and Reichardt, 1956 and Reiff et al., 2010). Our results define this computational architecture with respect to its input pathways (Figure 8B). As the calcium signals detected in L1 and L2 are not themselves rectified and as both pathways contribute to … Continue reading →

, 1995). N/OFQ and its receptor, NOPR, are widely expressed in the brain, where they control the release of other neurotransmitters through presynaptic actions (Darland et al., 1998; Neal et al., 1999). Despite its structural homology with opioid peptides, N/OFQ does not … Continue reading →

As a result, all currently known active zone proteins were identified based on antibodies, genetic mutations, or protein-protein interactions. Emerging evidence suggests that five evolutionarily conserved proteins—RIM, Munc13, RIM-BP, α-liprin, and ELKS proteins—form the core of active zones (Figure 2). RIM, … Continue reading →

, 1996). Thus far, most attention has been focused on short-term interactions between electrical and chemical synapses on the millisecond timescale, but it has long been speculated that chemical synapses may also drive long-term regulation of mammalian electrical synapses see … Continue reading →

The differences between syb2 and vti1a slope values during chemical stimulation are significant in both 2 and 8 mM extracellular Ca2+. Figures 4C and 4F depict the cumulative data as a percentage of total internal fluorescence after NH4Cl application. The inset … Continue reading →

The antibody readily detected TMEM16B-mCherry (monomer ∼132 kDa) expressed in HEK293 cells, but not in control cells cotransfected with enzymatically prepared small interfering RNA (esiRNA) (Kittler et al., 2005) targeting TMEM16B (Figure S3B). Using this rabbit anti-TMEM16B antibody to probe for the endogenous … Continue reading →

Follow-up studies will be needed to determine if the durability of the responses to two and three doses remain comparable. However, these results have already prompted some jurisdictions to initiate programs that delay administration of the third dose for at … Continue reading →