Monthly Archives: May 2017

Consistent with the notion that Nak functions with AP2, Nrg puncta were also diminished specifically in higher-order dendrites of the α-Adaptin-RNAi da neurons ( Figures 7G and S6). These results suggest that the localization of Nrg to higher-order dendrites requires … Continue reading →

Data was collected from at least four animals per group. The number and area of pERK-stained fibers increased significantly following intake of 1 ml water compared to a sham drinking control or to ingestion of 1 ml near-isotonic PBS (p < 0.01 compared … Continue reading →

serpentis in the stomach ( Ramirez et al., 2004 and Graczyk, 2008). The collection of at least five to seven fecal samples, and screening for Cryptosporidium oocysts by microscopy, is the most commonly recommended method for diagnosing cryptosporidiosis in snakes ( Graczyk … Continue reading →

Disruption in mice of key autophagy genes, such as Atg7 or Atg5, causes neurodegeneration and ubiquitin-rich inclusions ( Hara et al., 2006 and Komatsu et al., 2006). The neurodegeneration is associated with accumulation of aberrant organelles and stacks of cisternal membranes in the dystrophic … Continue reading →

, 1999 and Custer et al., 2006). Thus, decays of the basal synaptic transmission in EPAC−/− neurons could be also due to a reduction of Sv2b expression. Our electrophysiological recordings show that LTP is impaired in EPAC−/− neurons, indicating that functions of EPAC … Continue reading →

In the hippocampus, the labeling of all O-LM cell axons revealed their striking subcellular specificity. These axons form a prominent band in stratum lacunosum molecular, which contains the apical tufts of pyramidal neurons with a razor-sharp boarder with stratum radiatum … Continue reading →

(2010) study (seven animals). In this task, animals learned the locations of three new goals where food reward were hidden each day. The animal’s memory performance was assessed before and after the learning (preprobe and the postprobe sessions) and the … Continue reading →

Great strides in this direction have been made by Florian Engert and his colleagues, who have recently created zebrafish in which GCaMPs are expressed in all neurons, allowing activity to be assessed in multiple regions of the brain while filming … Continue reading →

, 2010). Thus, modulation of the proteomic composition of extracellular fluids together with the integration of cell autonomous determinants of self-renewal by the apical complex may ultimately provide unexpected ways to regulate stem cell behavior in health and SCH 900776 … Continue reading →

““Dopamine neurons of the ventral midbrain fire in distinct tonic and phasic patterns (Bunney et al., 1973, Grace and Bunney, 1984a and Grace and Bunney, 1984b), providing essential signals to cortical and striatal circuits responsible for various forms of motivation, learning, salience processing, … Continue reading →