Monthly Archives: March 2019

These results suggest that both MDR1 and MRPs are involved in DC maturation under LPS and hypoxia. In fact, our results under hypoxia point to a possible downstream mechanistic pathway via hypoxia-induced expression of HIF-1α. Interestingly, HIF-1α achieved similar values … Continue reading →

An unbalanced chromosomal translocation was found in all metaphases and confirmed by mFISH. The karyotype of the case is: 50∼99,XXX, +der(1;7)(q10;p10),inc[47] The derivative chromosome was found in all 47 analyzed cells, but the number of derivatives varied from one to … Continue reading →

38 We then determined if the phenotypic and endocytic differences between MoDCs and BDCs translated into differences in their ability to induce T-cell proliferation using autologous T cells. To this end, pigs were vaccinated with PTd and isolated cells were … Continue reading →

Moreover, other proteases have been indentified in chromaffines granules, including the neuroendocrine-specific carboxypeptidase E/H and the Lys/Arg-amino peptidases [55]. These data suggest that Cgs might serve as a prohormone for a shorter fragment having regulatory properties [56]. In the rat … Continue reading →

Various chemokine receptors, cytokine receptors, and pattern recognition receptors are expressed by γδ T cells and these receptors have been shown to be involved in the activation of γδ T cells, especially for the induction of IL-17 (Fig. 1). IL-1, … Continue reading →

The PDN and the combined PDN + taurine treatments have a similar effect on both histology and plasma enzyme profile. Then, we verified the real occurrence of a modification in taurine content in target tissues of animals undergoing the combined treatment. The … Continue reading →

We considered that this problem could be overcome by the eventual demise of plasma cells, alone or in combination with B cell depletion. However, plasma cells have very long half-lives, measured in months or even years [11]. Finally, in this … Continue reading →

Methods: Thoracic aortas removed from 10-week-old male Sprague-Dawley rats were cut into 3- to 5-mm rings and were cultured for 10 days. Phosphate concentration was titrated in the medium to induce vascular calcification. Ferric citrate was applied as an iron donor … Continue reading →

The hippocampus is particularly susceptible to perinatal HII (Nyakas, Buwalda, & Luiten, 1996). Many previous animal and human studies have demonstrated atrophy of the hippocampus and memory impairments following HII (Isaacs et al., 2003; Maneru et al., 2003; Mikati et al., 2005; Quamme, … Continue reading →

Sequencing of hotspot mutations and fluorescence in situ hybridization of relevant genes were undertaken. Median age at diagnosis of six patients was 7.6 years. Tumours originated in the cerebral cortex (n = 2) or diencephalon (n = 4). Three patients presented with acute, Idelalisib … Continue reading →