A partial response to treatment was achieved at the time of writing this report.”
“In our earlier study, we had reported the case of a patient with rheumatoid arthritis (RA), who had anti-Jo-1 antibodies. This patient had received etanercept (ETN) therapy for RA, after which she had developed overt polymyositis (PM). Although Proteasome inhibitor various autoimmune phenomena, including lupus-like diseases, vasculitides, or psoriatic skin lesions, are associated with antitumor necrosis factor (TNF) therapy, the development of PM/dermatomyositis (DM) or antisynthetase syndrome following anti-TNF therapy is extremely rare. Here, we report a case of an RA patient
with anti-PL-12 antibodies, who received ETN therapy and subsequently developed the antisynthetase syndrome. She recovered when ETN therapy was withdrawn and high-dose corticosteroid was administered. To date, there have been only five reported Sapitinib cost cases of RA patients with anti-Jo-1 antibodies who developed overt PM/DM following anti-TNF therapy and only one case of antisynthetase syndrome in an RA patient
with anti-PL-7 antibodies. Our patients and the abovementioned reports strongly suggest that onset of overt PM/DM or antisynthetase syndrome in RA patients with anti-aminoacyl tRNA synthetase antibodies is associated with anti-TNF therapy.”
“We demonstrate that slow light with large group-index, wideband, and low dispersion can be realized in a silicon-on-insulator W1-type photonic crystal waveguide by simply shifting the first two rows of air-holes adjacent to the waveguide to specific directions. Keeping the group index at 46, 60, 86, 111, 151, and 233, respectively, while restricting its variation within a +/- 10% range,
we accordingly obtain a slow light bandwidth of 9.0 nm, 6.7 nm, 4.6 nm, 3.3 nm, 2.4 nm, and 1.7 nm, respectively. The normalized delay-bandwidth product keeps around 0.25 for all cases. Moreover, we obtain ultraflat slow light with bandwidths over 3.0 nm, 2.4 nm, 1.6 nm, 1.3 nm, 0.93 nm, and 0.6 nm, respectively, where the group index variation is in a range of only +/- 0.8%. Numerical simulations are performed, utilizing the 2D plane wave expansion method and the finite-difference time-domain method. check details (C) 2011 American Institute of Physics. [doi:10.1063/1.3634074]“
“This study was conducted to determine the differences in the inter-observer agreement of the simplified Pelvic Organ Prolapse Quantification (POP-Q) system from center to center in a large international multicenter study.
This is a secondary analysis of the results of a large prospective single blind multicenter trial studying the inter-observer agreement of a simplified POP-Q exam. Twelve centers from four continents with a total of 511 subjects were included in this study. The number of subjects recruited per center ranged from 20 to 81.