Secondly, fabrication of series of functionalized cantilever Tofacitinib JAK3 arrays on micron scale is quite expensive and inconvenient. trichostatin a clinical trials Thirdly, there are several molecules which adsorb on the sensing layers through exothermic or endothermic reactions creating a resultant Inhibitors,Modulators,Libraries temperature change on the cantilever [5]. This can result in unwanted heat induced expansion/contraction thereby introducing erroneous results.As sensing materials, semiconducting transition metal oxides have been widely used for NO2 detection. Researchers have successfully reported NO2 detection using a wide range of transition metal oxides including In2O3 [16], SnO2 [17] and WO3 [18]. NO2 target molecules accept electrons from the transition Inhibitors,Modulators,Libraries metal oxides which creates changes in the electrical properties of the material.
Carbon has also showed itself to be an ideal sensing material due to its excellent molecular adsorption property [19]. Carbon based sensors, Inhibitors,Modulators,Libraries especially those utilizing carbon nanotubes (CNT), have been the focus for gas sensing during the last decade because of their high surface-to-volume ratio, excellent mechanical stiffness and hollow structure Inhibitors,Modulators,Libraries [20-23]. However, there are still significant challenges in large scale production and deployment of CNT based sensors. Carbon based sensors have been developed and researched almost exclusively using CNTs until the discovery of graphene in late 2004 [24, 25].
Graphene based functionalization layers have been shown to have molecular level sensitivity where one electron conductance change is reported to be detected with the adsorption of single NO2 molecule [26].
However, the Inhibitors,Modulators,Libraries search for a highly sensitive carbon based Inhibitors,Modulators,Libraries functionalization layer that is easy to Drug_discovery fabricate and economical to Inhibitors,Modulators,Libraries commercialize have still not concluded because of the lack of film control for graphene preparation.In this article, we demonstrate a highly sensitive microcantilever based detection technique that is generally applicable for the detection of gases and volatile chemicals, and eliminates the need for modifying the cantilever itself with a selective layer.
The Inhibitors,Modulators,Libraries technique is based on adsorption induced surface work function (SWF) change of the sensing layers; however unlike other SWF based sensors [27] it uses a microcantilever which Entinostat is resonated very near to a functionalized substrate with a setup similar to Kelvin probe technique (Figure 1) [5, 28].
In this work detailed analyses of the operation and sensitivity of kinase inhibitor Ivacaftor our microcantilever based detection technique is presented. SWF changes of different transition metal oxide thin films (Section 3.1) and carbon Axitinib clinical trial based layers (Section 3.2) in response to trace NO2 are also compared. Simultaneous potentiometric and amperometric measurements on nanostructured graphite (NG) layers are discussed at the end of the article in Section 3.3.Figure 1.