When comparing the 2009 survey data from Sweden to the current data, the number of bleeding episodes per year in the Always on Prophylaxis group was zero to three compared to the current study of four to seven bleeding episodes per year . There was also a higher prevalence of target joints in this survey in the Always on Prophylaxis group (26.5% in 2009 vs. 40% in 2011) as well as a reduction in the health utility value for the Always on Prophylaxis group between the current survey (0.87) and the 2009 survey (0.88), which may be a result of the difference
between the Dutch and the Malmö regimens. There was a reduction in the health utility value in the Always On-Demand group from 0.72 in 2009 to Saracatinib clinical trial 0.619 in 2011, possibly due to the relative lack of organization of haemophilia care and lack of resources
for haemophilia in Poland in the past. The use of a long-term prophylaxis as implemented in the Netherlands shows a clear benefit over all other countries in the survey as the LDE225 mw respondents had the lowest rate of target joints (40%), serious bleeding episodes (25%) and problems with recurring bleeding episodes (25%) compared to all countries. It is the only country with no patients requiring invasive surgical procedures and has a mean of 0.5 joints that are reported as having reduced mobility. In comparison the respondents from Poland, had a twofold higher presence of target joints, a 3.2-fold higher occurrence of serious bleeding episodes and recurrent bleeding and a fivefold increase 上海皓元医药股份有限公司 in presence of daily pain as a result of their bleeding disorder and a sixfold increase in joints with reduced mobility. The Polish health utility value (0.624), was lower by 31% and 20% compared with the Netherlands and Ireland respectively. The Polish utility value is lower than that which has previously
been found in 60 year old patients with cancer . Although not statistically significant, Poland has the highest rate of early retirement due to bleeding problems at 15% of the group with a mean age at retirement of 32 years, clearly demonstrating that the lack of prophylactic treatment available to the Polish respondents in childhood has had a significant long-term impact on the quality of their lives, especially when compared to the Dutch group. Despite the significant differences between the two groups, the reported mean factor consumption for both countries in the last year (September 2010–September 2011) was the same at 169 000 IU per patient suggesting that long-term prophylaxis may not only improve the quality of life but may also be cost effective in the long term. As a result of many target joints, the Polish respondents use similar quantities of treatment for on-demand therapy as the Netherlands respondents do for prophylaxis based on a relatively low-dose regimen.