001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The crude extract produced the most prominent cytotoxic activity against brine shrimp Artemia sauna (LC50 = 5.5 mu g/ml and LC90 = 9.3 mu g/ml). The extract showed antidiarrhoeal activity on castor oil induced
diarrhoea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the Selleck Vorinostat oral dose of 250 and 500 mg/kg body weight (P < 0.01) comparable to the standard drug Loperamide at the dose of 50 mg/kg of body weight. The obtained results provide a support for the use of this plant in traditional medicine and its further investigation.”
“To investigate whether rs11190870 near LBX1 correlates with the susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in a Han Chinese population.
A total of 949 AIS patients and 976 age-matched healthy controls were recruited. All the subjects were genotyped using the PCR-based invader assay. Case-control study and case-only Z-DEVD-FMK mw study were performed to define the contribution
of rs11190870 to predisposition and curve severity of AIS. Additionally, we further conducted a meta-analysis of the study findings together with those of previously reported studies.
A significant association of rs11190870 with AIS was AZD6738 cost observed in the Han Chinese population (P = 1.8 x 10(-9); odd ratio = 1.51; 95 % confidence interval = 1.33-1.71), and AIS patients with TT genotype had a larger Cobb angle than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population.
The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS.”
“Diabetes mellitus is a metabolic disease associated to oxidative stress. In this work, the hypoglycaemic and antioxidant effect of an extract of Physalis peruviana fruits in an experimental diabetes model was evaluated. The diabetes was induced in Wistar rats
by a single administration of streptozotocin. The oxidative stress markers evaluated were lipid peroxidation, protein oxidation, ferric reducing ability of plasma (FRAP) and the superoxide dismutase and catalase activities in pancreas, liver and kidney. The oral administration of Physalis peruviana extract during 15 days reduced the blood glucose levels further than 30 %. The same way, the extract administration increased the FRAP levels and the superoxide dismutase and catalase activities. The lipid peroxidation and protein oxidation levels were reduced. The results suggest that the Physalis peruviana extract exhibit hypoglycaemic activity and improve the antioxidant status of the streptozotocin diabetic animals.