1996; Seward 1996). If the authors believed that their ACP-196 solubility dmso patients were severely poisoned, why did they not initiate chelation therapy for them? If the patients’ poisoning was not so severe, why the authors concluded that plasma lead had
been about 20 μg/L at severe poisoning? I think, with respect to the patients’ clinical manifestations and blood lead levels [median blood lead level at first sampling was 790 (520–1,600) μg/L], their cases had mild to moderate poisoning (not severe) (Kosnett 2007; Henretig 2011), and their conclusion seems not to be correct. Thanks for this interesting study. Conflicts of interest None. References Henretig FM (2011) Lead. In: Nelson LS, Lewin NA, Howland MA, Hoffman RS, Goldfrank LR, Flomenbaum NE (eds) Goldfrank’s toxicologic emergencies, 9th edn. McGraw-Hill, New York, pp 1266–1283 Kosnett MJ (2007) Lead. In: Olson KR Rapamycin (ed) Poisoning
and drug overdose, 15th edn. McGraw-Hill, New York, pp 237–242 Rentschler G, Broberg K, Lundh T, Skerfving S (2011) Long-term lead elimination from plasma and whole blood after poisoning. Int Arch Occup Environ Health, June 24 [Epub ahead of print] Romeo R, Aprea C, Boccalon P, Orsi D, Porcelli B, Sartorelli P (1996) Serum erythropoietin and blood lead concentrations. Int Arch Occup Environ Health 69(1):73–75CrossRef Saryan LA, Zenz C (1994) Lead and its compounds.
In: Zenz C, Dickerson OB, Horvath EP Jr (eds) Occupational CHIR-99021 datasheet medicine, 3rd edn. St. Louis, Mosby, pp 506–541 Seward JP (1996) Occupational lead exposure and management. West J Med 165:222–224″
“Introduction Mental health complaints such as stress, mild depression, and anxiety disorders, often referred to as common mental disorders (CMDs), can lead to impairments in work performance (Aronsson et al. 2000; Hilton et al. 2008; Lerner et al. 2004; Lerner and Henke 2008; McKnight and Kashdan 2009). These impairments result not only in lower productivity; but in certain occupations, they can have serious consequences as well, e.g., in the work of nurses and allied health professionals. In these professions, consequences of impaired work functioning can affect the health of the caregiver as well their patients. Examples of these deleterious effects include medication errors, needle stick injuries, near errors, and decreased patient satisfaction (Gartner et al. 2010). These consequences are even more noteworthy given the high incidence of CMDs in this occupational group. The relative risk of depression is highest for nurses, RR = 3.5, 95% CI (1.3, 9.6), as compared with other human service workers and other healthcare workers (Wieclaw et al. 2006).