3 FollowupDuring the entire the followup period, the older adult

3. FollowupDuring the entire the followup period, the older adults were monitored every six months by means of either phone calls or medical appointment. Individuals who were not found after an active search using addresses, selleck chemicals llc health insurance, retirement, and mortality data were considered as losses and censured in the analysis model subsequent to the last followup contact date.2.4. Statistical AnalysisData were stored and analyzed using the program EPINFO��version 3.5. The significance level was set at 5%. The chisquare test was used to compare the sample characteristics according to gender for categorical variables. Analysis of variance (ANOVA) was used to compare numerical variables with homogenous variances; otherwise the Kruskal-Wallis test was used.

Cumulative survival probability was computed using Cox proportional hazards modeling; the outcome analyzed was all-cause mortality and the independent variables were dyslipidemias, which were presented as categorical variables. The regression model was adjusted for gender, age range >75 years old, hypertension, and diabetes.A second analysis was carried out with a model adjusted for gender, age range, hypertension and diabetes, but excluding the older people who died in the first two years or whose BMI dropped to <20kg/m2. The purpose for excluding patients who died prematurely or became underweight was to reduce the impact of preexisting diseases as the cause of death and to minimize the interference of low weight on cholesterol levels, malnutrition and mortality.2.5.

Ethical AspectsThis study was approved by the Ethics Committee of the Universidade Estadual de Londrina, and all patients provided written informed consent at the beginning of followup.3. ResultsThe sample consisted of 800 individuals from 60 to 85 years old (mean age = 71.2; median = 70.5) and was predominantly female (66.7%). Mean followup time for those whose outcome was not presented was 146.6 months. Followup with 38 people was lost (4.8%). Three-hundred thirty-nine deaths were registered (42.9%), being more frequent among men (48.9%). Mean TC, non-HDL-c, HDL-c, and LDL-c were higher among women. High blood pressure was more frequent among women and smoking was more frequent among men (Table 1).Table 1Characterization of older people according to sex.In the Cox proportional hazard analysis adjusted for gender, age range >75 years, hypertension, and diabetes, there was a positive association between mortality and the total cholesterol <170mg/dL variable. The variables total cholesterol >200mg/dL, cholesterol non-HDL >170mg/dL, and LDL-c >130 and >100mg/dL were negatively associated with mortality (Table 2).Table 2All-cause mortality Carfilzomib risk and lipid levels in adjusted by sex, age >75, hypertension, and diabetes.

This entry was posted in Antibody. Bookmark the permalink.

Leave a Reply

Your email address will not be published. Required fields are marked *

*

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>