5-83 years of age. Slow wave activity related to strategic monitoring was reliable across the lifespan suggesting that all ages were able to allocate attentional resources to facilitate PM. Additionally, components of the ERPs related to cue detection, switching, and task configuration were reliable across the lifespan, suggesting that similar processes contribute to PM at all ages. In children, PM errors may have resulted from a decoupling of processes supporting cue detection and switching from the ongoing activity
to the prospective element of the task. In younger and older adults. PM errors appeared to result from the failure to detect PM cues in the check details environment. These findings lead to the conclusion that different processes may contribute to variation in PM across the lifespan. (C) 2011 Elsevier Ltd. All rights reserved.”
“Aims:
The objective of this study is to optimize the levels of carbon and nitrogen sources of the medium in shake flask experiments and evaluate the effect of pH and dissolved oxygen (DO) on the production of l-asparaginase from a newly
isolated Serratia marcescens SK-07 in a batch bioreactor.
Methods and Results:
Central CP673451 order composite rotatable design (CCRD) was applied to optimize the levels of carbon and nitrogen sources of the medium in shake flask experiments. The optimal levels of l-asparagine, glucose, yeast extract and peptone were found to be 4 center dot 93, 3 center dot 81, 3 center dot 65 and 1 center dot 47 g l-1, respectively, and maximal l-asparaginase production of 25 center dot 02 U mg-1 was obtained Ketotifen under these conditions. Among the carbon sources tested, l-asparagine was identified to be the most favourable carbon source for enhanced production of l-asparaginase. The maximum l-asparaginase production of 29 center
dot 89 U mg-1 was achieved in a batch bioreactor at initial pH of 6 center dot 5 (uncontrolled) and DO level of 40% in the culture.
Conclusions:
We have isolated, screened and identified the potential micro-organism, S. marcescens, for the production of l-asparaginase. An overall 5 center dot 55-fold increase in the production was achieved under optimal levels of carbon and nitrogen sources, DO level and at initial pH of 6 center dot 5 (uncontrolled).
Significance and Impact of the Study:
The experiments illustrate the importance of statistical method for optimization of carbon and nitrogen sources and study the effect of physical process parameters on the production of l-asparaginase in shake flask and bioreactor, respectively. This study would be helpful for bioprocess development of bacterial l-asparaginase production.”
“Synchronization of EEG alpha activity has been referred to as being indicative of cortical idling, but according to more recent evidence it has also been associated with active internal processing and creative thinking.