5 mg/kg) were asymptomatic. Both motor activity and acoustic startle response are sensitive measures for assessing selleck screening library the effects of pyrethroids at doses far below those producing convulsions.
Infection challenge with C. albicans either pre- or post-exposure to deltamethrin caused increase in the CFU both in liver and spleen. The ability of a pathogen to cause infection depends on a successful invasion of the host, which, in turn, requires that the various host defence mechanisms are not working to their full potential. For the host, an infectious process is a highly complex situation to deal with, even in situations where the immune system is not disturbed by toxic chemicals or in the deficiency Dabrafenib datasheet of essential nutrients [27–29]. Evidence on modulation of white blood cells and lymphocyte populations by deltamethrin is limited and seems to be dependent on age, sex and species of the animals [19]. Our study shows that deltamethrin has a potential
to compromise the immunity and impair host resistance to C. albicans infection in mice. In a recent report by Suwanchaichinda et al. [30], mice exposed to deltamethrin in soyabean oil by gavage at doses of 5 and 10 mg/kg showed immunosuppression and enhanced susceptibility to malaria infection (Plasmodium berghei). Deltamethrin induced thymus atrophy by interfering with the cell signalling cascades in male BALB/c mice injected i.p. with a single dose of 25 mg/kg [31]. The immunosuppressive properties
of deltamethrin can be ascribed to its ability buy Abiraterone to diffuse into cells via its property of liposolubility and inhibitory effect on protein synthesis. These reports show that as a result of exposure to deltamethrin there is a risk of weakened resistance to infection challenge. CFU in liver remained high in deltamethrin treated mice. In spleen and liver, CFU were more than deltamethrin alone treated animals. This shows a high infection rate in spleen and liver. When mice were treated with deltamethrin before and after the challenge by C. albicans, it significantly suppressed the humoral immune response. Lymphocytes play a major role in immune defense against the bacterial infections [32, 33]. For instance, TH1 cells and interferon-γ are required to control the primary peak parasitemia in mice infected with Plasmodium chabaudi and this mechanisms is antibody-independent [34]. CD4 + TH1 and TH2 cells and antibodies are required after the peak to eliminate the parasites. Depletion of natural killer cells can also cause a rapid increase in fungal or bacterial infection [35]. Studies on the insecticide sulfluramid caused suppression ranging from 70 to 89% (6–57 μmol/kg/day) in mice [36]. Decreases in IgG classes (IgG1, IgG2b, IgG3) were also reported following exposure to perfluoroctanic acid for 10 days [37]. Taken together, our data suggest that humoral immunological function may be a target for pesticides.