As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Figure S1: Specificity and viability control of IRAK4 siRNA. Figure S2: Small molecule inhibitor controls. “
“Citation Mor G, Cardenas I. The immune system in pregnancy: LDK378 in vivo a unique complexity. Am J Reprod Immunol 2010 Placental immune response and its tropism
for specific viruses and pathogens affect the outcome of the pregnant woman’s susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. Selumetinib nmr There is a need to evaluate the interaction of each specific pathogen with
the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge
as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the ‘classical concepts’ to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios. Viral or bacterial pandemics threaten the general this website population; however, there are special populations, such as children and pregnant women, which may be at a higher risk and more susceptible to or more severely affected by infectious diseases. Pregnant women are considered to be a special population group due to their specific susceptibility to some infectious diseases because of the unique ‘immunological’ condition caused by pregnancy. Therefore, pregnancy presents many challenges for making decisions on how to approach, prevent and treat infectious diseases. The most challenging questions include the following: (1) are pregnant women more susceptible to infectious disease threats?, (2) how does a viral infection affect the fetus and the pregnancy outcome?, (3) are prophylaxis and treatment appropriate and beneficial for pregnant women? The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions.