In HAE, type I interferon (IFN) is induced following infection
with an HPIV1 mutant expressing defective C proteins with an F170S amino acid substitution, rHPIV1-C-F170S, but not SBI-0206965 following infection with wild-type HPIV1. IFN induction coincided with a 100- to 1,000-fold reduction in virus titer, supporting the hypothesis that the HPIV1 C proteins are critical for the inhibition of the innate immune response. Two recently characterized live attenuated HPIV1 vaccine candidates expressing mutant C proteins were also evaluated in HAE. The vaccine candidates, rHPIV1-(CHNLY942A)-H-R84G/Delta 170-L-T553A and rHPIV1-(CHNL Delta 1710-11)-H-R84G/Delta 170-L-T553A, which contain temperature-sensitive (ts) attenuating (att) and non-ts att mutations, were highly restricted in growth in HAE at permissive (32 degrees C) and restrictive (37 degrees C) temperatures. The viruses grew slightly better
at 37 degrees C than at 32 degrees C, and rHPIV1-(CHNLY942A)-H-R84G/Delta 170-L-T553A was less attenuated than rHPIV1-(CHNL Delta 1710-11)-H-R84G/Delta 170-L-T553A. The level of replication in HAE correlated with that previously observed for African green monkeys, suggesting that the HAE model has potential as a tool for the preclinical evaluation of HPIV1 vaccines, although how these in vitro data will correlate with vaccine virus replication in seronegative human subjects remains to be seen.”
“OBJECTIVE: Paraophthalmic aneurysms may exert this website mass effect on the optic apparatus. Although surgical clipping and endovascular coiling of these aneurysms can be complicated by immediate
postoperative visual deterioration, endovascular coil embolization has the unique risk of visual complications see more later (>24 h) in the perioperative period.
METHODS: Six patients with a delayed onset of vision loss after technically successful coil embolization of paraophthalmic region aneurysms were identified. All available clinical, angiographic, and cross sectional imaging for these patients, in addition to histopathological data, were reviewed.
RESULTS: Six patients who underwent endovascular treatment of paraclinoid aneurysms at our institutions developed delayed postoperative visual decline. Four were treated with combination hydrogel-coated and bare platinum coils, one with hydrogel-coated coils, and one with bare platinum coils. Three patients presented with some degree of visual impairment caused by their aneurysms. Catheter angiography performed after the visual decline revealed no etiology in any of the cases. Magnetic resonance imaging was performed in all patients and was unremarkable in two. At follow-up, two had improved, three remained unchanged, and one patient died before any follow-up assessment of her vision.
CONCLUSION: Both acute and delayed visual disturbances can present after the endovascular treatment of carotid artery paraophthalmic aneurysms.