Infect Immun 2007, 75:4710–4718.PubMedCrossRef 15. Netea MG, Gijzen K, Coolen N, Verschueren I, Figdor C, Van der Meer JW, Torensma R, Kullberg BJ: Human dendritic cells are less potent at killing Candida albicans than both monocytes and macrophages. Microbes Infect 2004, 6:985–989.PubMedCrossRef 16. Shao X, Mednick A, Alvarez M, van Rooijen N, Casadevall A, Goldman DL: An innate immune system cell is a major determinant
of species-related susceptibility differences to fungal pneumonia. J Immunol 2005, 175:3244–3251.PubMed 17. Zaragoza O, Alvarez M, Telzak A, Rivera J, Casadevall A: The relative susceptibility of mouse strains to pulmonary Cryptococcus neoformans infection Apoptosis inhibitor is associated with pleiotropic differences in the immune response. Infect Immun 2007, 75:2729–2739.PubMedCrossRef 18. Colonna M, Pulendran B, Iwasaki A: Dendritic cells at the Everolimus chemical structure host-pathogen interface. Nat Immunol 2006, 7:117–120.PubMedCrossRef 19. Gacser A, Salomon S, Schafer W: Direct transformation of a clinical isolate of Candida parapsilosis using a dominant selection marker. FEMS Microbiol Lett 2005, 245:117–121.PubMedCrossRef
20. Eissenberg LG, Goldman WE, Schlesinger PH: Histoplasma capsulatum modulates the acidification of phagolysosomes. J Exp Med 1993, 177:1605–1611.PubMedCrossRef 21. Shi L, Albuquerque PC, Lazar-Molnar E, Wang X, Santambrogio L, Gacser A, Nosanchuk JD: A monoclonal antibody to Histoplasma capsulatum alters the intracellular fate
of the fungus in murine macrophages. Eukaryot Cell 2008, 7:1109–1117.PubMedCrossRef 22. Fernandez-Arenas E, Bleck CK, Nombela C, Gil C, Griffiths G, Diez-Orejas R: Candida albicans actively modulates intracellular membrane trafficking in mouse macrophage ROS1 phagosomes. Cell Microbiol 2009, 11:560–589.PubMedCrossRef 23. Marcil A, Gadoury C, Ash J, Zhang J, Nantel A, Whiteway M: Analysis of PRA1 and its relationship to Candida albicans- macrophage interactions. Infect Immun 2008, 76:4345–4358.PubMedCrossRef 24. Lazzaro BP, Rolff J: Immunology. Danger, microbes, and homeostasis. Science 2011, 332:43–44.PubMedCrossRef 25. Matzinger P: The danger model: a renewed sense of self. Science 2002, 296:301–305.PubMedCrossRef 26. Strieter RM, Kunkel SL, Showell HJ, Remick DG, Phan SH, Ward PA, Marks RM: Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science 1989, 243:1467–1469.PubMedCrossRef 27. Liu AY, Destoumieux D, Wong AV, Park CH, Valore EV, Liu L, Ganz T: Human beta-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 2002, 118:275–281.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions FK, TN and AG carried out the phagocytosis and QRT-PCR studies, participated in the protein measurement experiments. ZSH, IN and AG participated in the infection studies.