It is hoped Buparlisib clinical trial that the consensus strategies will be updated regularly and adopted by health authorities to improve the care of patients with HCCA in many other countries outside the Asia–Pacific region as well. “
“We read the excellent article by Harrison et al.,1 who showed that elevated baseline low-density lipoprotein levels are associated with higher sustained virological response (SVR) rates. In our experience with 32 transplant patients who suffered hepatitis C recurrence and were treated with peginterferon
alfa-2b and ribavirin, the total cholesterol (TC) levels (mg/dL) did not influence SVR.2 In this particular group of patients, the importance of parameters such as the body mass index (BMI; kg/m2), triglyceride (TGC) levels (ng/mL), and hepatic percentage of steatosis in the response to antiviral therapy was demonstrated. Ten patients (31.2%) stopped their therapy because of side effects. The observed BMI values, TC levels, TGC levels, and percentages of steatosis were confirmed to be normally distributed by the one-sample Kolmogorov-Smirnov
goodness-of-fit test procedure. Comparisons of the BMI values, TC levels, TGC levels, and percentages of steatosis this website between nonresponse (NR), SVR, and sustained biochemical response (SBR) groups were analyzed by analysis of variance with the post hoc Bonferroni test, and correlations between variables were tested with the Pearson test. A univariate analysis was
performed to estimate the chance of a response according to the aforementioned variables. The BMI values (26.8 ± 3.3 kg/m2), TGC levels (245.3 ± 84.4 ng/mL), and percentages of steatosis (26.8% ± 23.6%) in the NR group (nine cases) were higher than those observed in the SVR group [six cases; 20.4 ± 2.6 kg/m2 (P < 0.001), 108.3 ± 48.4 ng/mL (P = 0.002), and 5.75% ± 2.2% (P = 0.027), respectively] and in the SBR group [seven cases; 21.5 ± 1.6 kg/m2 (P = 0.003), 132.4 ± 51.2 ng/mL (P = 0.008), and 6.2% ± 2.4% (P = 0.033), respectively]. The differences Fludarabine manufacturer between the SVR and SBR groups were not significant for the aforementioned variables. As for cholesterol, no significant differences were registered between the NR group (197.6 ± 47.3 mg/dL), the SVR group (149.3 ± 37 mg/dL), and the SBR group (153.4 ± 41.5 mg/dL). The Pearson correlation test (correlation coefficient >0.7, P < 0.001 for every correlation) showed a strong correlation between the BMI values, cholesterol levels, TGC levels, and percentages of steatosis. For patients with a BMI <25 kg/m2 and TGC levels < 160 ng/mL, the chance of SVR was 48 times higher than the chance of NR.