Ion of p53 by ATM in response to DNA-Sch The. Science 1998, 281:1674 �. 9th Canman CE, Wolff AC, Chen CY, Fornace AJ Jr, Kastan MB. P53-dependent Controlled Independent G1 cell The bike path and ataxia-telangiectasia. Cancer Res 1994; 54:5054 �. 10th Canman CE, Lim DS, Cimprich KA, et al. ATM kinase activation by Givinostat ITF2357 ionizing radiation and phosphorylation of p53. Science 1998, 281:1677 �. 11th Matsuoka S, Rotman G, Ogawa, A., et al. Ataxia telangiectasia mutated Chk2 phosphorylated in vivo and in vitro. Proc Natl Acad Sci U S A 2000; 97:10389 � 4. 12th Maya R, M Balass, ST Kim et al. ATM-dependent phosphorylation of Mdm2 on serine Independent 395: R in the activation of p53 by DNA-Sch ending. Genes Dev 2001, 15:1067 7 �. 13th Kim ST, Xu B, Kastan MB.
The participation of the carbon Sin protein, SMC1, in ATM-dependent Independent responses and Panobinostat independent Stranded DNA-Sch To. Genes Dev 2002; 16:560 � 0th 14th Lim DS, Kim ST, Xu B, et al. ATM phosphorylates checkpoint p95/nbs1 way into the S phase, Nature 2000, 404:613 �. 15th Taniguchi T, Garcia-Higuera I, Xu B, et al. Convergence of the Fanconi On Ataxia telangiectasia signaling pathways and chemistry. Cell 2002; 109:459 � second 16th Xu B, O � �D onnell AH, Kim ST, Kastan MB. Phosphorylation of serine 1387 in BRCA1 is specifically designed for the ATM-mediated S phase checkpoint after ionizing radiation is required. Cancer Res 2002; 62:4588 one �. 17th Bao S, Tibbetts RS, Brumbaugh KM, et al. ATR / ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. Nature 2001, 411:969 � 4th 18th Petrini JH.
The S-Mre11 complex mammal Rad50-NBS1 proteins: integration of functions in the cellular DNA-Ren Sch the reaction. Am J Hum Genet 1999; 64:1264 �. 19th Scully R, Livingston DM In search of tumor-suppressor functions of BRCA1 and BRCA2. Nature 2000; 408:429 � second 20th Choudhury A, Cuddihy A, Bristow RG. Radiation and new molecular agents part I: The targeting of checkpoints, repair of DNA ATMATR, and the proteasome. Semin Radiat Oncol 2006; 04.51 clock �. 21st Eastman checkpoints A. The cell cycle and its impact on therapeutic strategies against cancer. J Cell Biochem 2004; 91:223 a �. 22nd Sarkaria, JN, Eshleman JS. ATM as a target for novel radiosensitizers. Semin Radiat Oncol 2001; 11:316 7 �. 23rd Kastan M. Ataxia-telangiectasia – broad implications for a rare disease.
N Engl J Med 1995; 333:662 �. 24th Hickson I, Zhao Y, Richardson CJ, et al. Identification and characterization of a new specific inhibitor of ATM and ataxia telangiectasia mutated kinase. Cancer Res 2004; 64:9152 �. Rainey et al. Cancer Res 10 Page. Author manuscript in PMC 15th September 2009. NIH-PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author Manuscript 25th Bakkenist CJ, Drissi R, Wu J, Kastan MB, Dome JS. The disappearance of the stress response dysfunctioninduced completely telomeres in aging cells, YOUR BIDDING. Cancer Res 2004; 64:3748 � second 26th Wood LD, Halvorsen TL, Dhar S, et al. Ataxia telangiectasia fibroblasts with the characterization of engaged Ngerter life through the expression of telomerase. Oncogene 2001; 20:278 8 �. 27th Kamijo T, van de Kamp E, Chong MJ, et al.
The loss of the ARF tumor suppressor versa premature replicative arrest but not radiation hypersensitivity, the disabled from ATM function. Cancer Res 1999; 59:2464 �. 28th RT Williams, The Best W, Sherr CJ. Cytokine-dependent Independent imatinib resistance in mouse BCR-ABL +, Arf-null lymphoblastic leukemia Chemistry. Genes Dev 2007; 21:2283 �. 29th Kim ST, Lim DS, Canman CE, Kastan MB. Substrate specificity Th and identification of substrates of Mutma Lay members of the ATM kinase family. J Biol Chem 1999; 274:37538 � third 30th Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB. Phosphorylation of SMC1 is a critical event in the downstream signaling pathway ATM-NBS1-BRCA1. Genes Dev 2004; 18:1423 8 �. 31st Xu B, Kim ST, Lim DS, Kastan MB. Two different molecular weight G / M
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