Key Word(s): 1. Adipogenic; 2. Hepatocytes; 3. Cytokines; 4. NAFLD; Presenting
Author: MARA BARBOSA Additional Authors: SILVIA LEITE, CARLA MARINHO, JOSE COTTER Corresponding Author: MARA BARBOSA Affiliations: CENTRO HOSPITALAR DO ALTO AVE – GASTROENTEROLOGY DEPARTMENT Objective: Recent data suggest that a decrease in liver elasticity is observed with increasing fibrosis in non-alcoholic fatty learn more liver disease (NAFLD). Metabolic syndrome is a known risk factor for non-alcoholic steatohepatitis and advanced fibrosis. To verify if metabolic syndrome is associated with a decrease in liver elasticity in NAFLD patients. To investigate the relationship between liver elasticity and demographic variables, body mass index (BMI), waist circumference and steatosis grade. Methods: Prospective study that included non-cirrhotic NAFLD patients. Variables analyzed: sex, age, metabolic syndrome (defined by NCEP/ATPIII criteria), ultrasound steatosis grade (classified as mild, moderate and severe) and liver elasticity (assessed by real-time find more elastography and defined by tissue mean elasticity (TME)). Statistical significance
was established at p < 0.05. Results: Thirty patients were evaluated, with 5 being excluded because of low-quality elastography information: 13 women, mean age of 53 years, mean BMI of 30 kg/m2, mean waist circumference of 101 cm. The prevalence of metabolic syndrome was 60% (n = 15). Steatosis
grade: mild in 13 patients, moderate in 10 and severe in 2. Mean TME was 105 ± 8. Patients with metabolic syndrome did not have lower TME values (105 vs 104; p = 0.848). TME showed a negative correlation with age (p = 0.026) and waist circumference (p = 0.013). TME values were higher in male patients (p = 0.007). TME did not correlate with BMI nor with steatosis grade (p = 0.131; p = 0.185). Conclusion: In NAFLD, liver elasticity assessed by real-time elastography inversely correlated with waist circumference and age. Nevertheless, there medchemexpress was no association with the presence of metabolic syndrome. Women had lower values of liver elasticity. Key Word(s): 1. elastography; 2. liver; 3. elasticity; 4. metabolic syndrome; Presenting Author: YING HU Additional Authors: HENGHUI ZHANG, JING LI, XU CONG, YANHUI CHEN, GAIXIA HE, YUJING CHI, YULAN LIU Corresponding Author: YULAN LIU Affiliations: Peking University People’s Hospital,; Peking University People’s Hospital, Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Beijing 100044, P. R. China.; Department of Gastroenterology, Peking University People’s Hospital, Beijing100044, P. R. China.; Institute of Clinical Molecular Biology, Peking University People’s Hospital, Beijing 100044, P. R. China.; Department of Gastroenterology, Peking University People’s Hospital, Beijing 100044, P. R. China.