KSP Inhibitors loop is interrupted and activated MEK MEK accumulated.

For example, if KSP Inhibitors MEK1 is aligned, ERK1, was inhibited by 2 and the negative feedback loop is interrupted and activated MEK MEK accumulated. However, when Raf is also inhibited, there may m Be possible, YOUR BIDDING to close S the street e This is a rationale for treatment with both MEK and Raf inhibitors. In Similar way that both PI3K and mTOR may be more effective than targeting either PI3K or mTOR itself. If there is a simple inhibitor, both molecules, such as inhibitors of PI3K and mTOR has new twin objectives, this is a realistic therapeutic. Closing Lich is a new concept of dual alignment of two different signal transduction pathways, Raf / MEK / ERK and PI3K/PTEN/Akt/mTOR example. This was investigated in some pr Clinical models, as discussed in the text.
The reason for the alignment of these two paths, k Can abh Ngig of the presence of mutations in either / or both canals len or upstream Rts of Ras in particular cancer, both ways can be activated. However, it is not clear at this point in time, that the targeting two different kinases in the same or two different kinases clinically in two different ways, with two different inhibitors are KSP inhibition in the near future. Although it may be scientifically interesting and effective, it may be clinically unm Possible. He can tet further clinical sense, a target kinase and also with a chemotherapeutic agent, the cells abt. It is not always understand why a particular combination of an inhibitor of signal transduction and chemotherapy drug that works in a tumor type, but not at all clear, in a different type of tumor.
This was also the experience with the development of various chemotherapeutic agents some work in some cells, but not others. This can consist of many complex events that lead to interact. Some of these events go nnten k Ren: percentage of cells in different phases of the cell cycle, the persistence of CIC and many other factors. . Nally Impactjournals.com / Oncotarget oncotarget 153 2011, 2: 135-164 foreign chemotherapy and other types of therapy can sen k distinct signaling pathways. The induction of these pathways may counteract some effects of inhibitors of signal transduction. Scientists and clinicians are often unaware narrow view of a particular topic. For example, sch COLUMNS The researchers found that cancer mainly Raf, MEK, inhibitors of PI3K, Akt and mTOR is the growth of b Sartigen suppress cancer cells.
However, MEK and mTOR inhibitors, and others can also in the treatment of autoimmune diseases and allergies where there is abnormal cell proliferation useful. Recently, it was observed that the suppression of the Ras / Raf / MEK / ERK and Ras/PI3K/Akt/mTOR orbits, the induction of cellular prevent Ren senescence and aging. Obviously, these two clinical Chern F, Improve immune diseases and aging strongly the m Possible clinical applications of targeted therapeutics. Deacetylases are a family of enzymes that catalyze the removal of acetyl groups from lysine residues, and to this day are examined in detail in connection with histones. Inhibitors of these enzymes were first Highest reported to relieve transcriptional repression and epigenetic result of histone deacetylation. It is now clear that the targets of these enzymes also have a wide range of proteins Such as transcription factors, chaperones, components of signaling and cytoskeletal proteins. Thus, the effects of inhibitors of CAD