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Pericytes and is a very interesting approach that deserves further investigation. In summary, for the treatment of Limonin cancers of epithelial ovarian cancer antivaskul Re a promising approach, which are still approved as part of Phase III will have. Asmany patients as m Possible should be encouraged to participate in clinical trials take good con Us. Introduction In the United States and Europe are beautiful tzungsweise 192 000 346 000 new F and ll Of prostate cancer diagnosed each year, respectively. In advanced prostate cancer, is the standard first-line anti-androgen therapy with medical or surgical castration. Although most patients who initially responded to treatment with closing castration, prostate cancer Below if, despite castrate levels of androgens.
The first clinical symptoms of progressive CRPC go Ren increased antigen concentration Ht prostatespecific and severe pain in 90% and 35% of diabetes patients. Progress as CRPC, to about 90% of patients Triciribine develop bone metastases and 20% develop metastatic soft tissue, at the hour Ufigsten in the lungs, liver or lymph nodes. Currently, prostate cancer with bone metastases is considered incurable. The median survival time of patients with bone metastases concerning gt About 20 months and will rise with chemotherapy and other new agents.
Shops ftsf��hrer the Lebensqualit t is in this patient group is therefore particularly important and probably with the formation of new bone-specific therapies, such as improved inhibitors of receptor activator of nuclear factor B ligand , and the increasing concentration of patients with bone metastases in general management Abbreviations: BAP, bone alkaline phosphatase, ECB, equivalent bone collagen, BP, bisphosphonate, BSP, bone sialoprotein, CRPC, castration-resistant prostate cancer, the CTC, circulating tumor cells, CTX, carboxy-terminal telopeptide of type I collagen, DPD, deoxypyridinoline, ELISA, enzyme immunoassay, FMS, macrophage colony-stimulating factor receptor, HPLC, HPLC, ICTP, carboxy-terminal cross-linked telopeptide of type I collagen, IRMA, immunoradiometric assay, IV intravenous, se, NTX, amino-terminal telopeptide of type I collagen, OC, osteocalcin, OPG, osteoprotegerin, PICP, carboxy-terminal propeptide of type I procollagen, PINP, aminoterminal propeptide of procollagen type I, PR, partial response, PSA, prostate-specific antigen, RANKL receptor activator of nuclear factor B ligand , RECIST, tartrate-resistant response criteria in solid tumors, RIA, radioimmunoassay, SD, stable disease, SELDI TOF-MS, Surface Enhanced Laser Desorption / Ionization Time of Flight Mass Spectrometry, SRE, skeletal related event, TRACP5b The acid phosphatase 5b-type serum, uNTx, urinary NTX Address correspondence to: Janet E.
Brown, the Cancer Research UK Clinical Centre, Leeds Institute ofMolecularMedicine, University of Leeds, Brenner Building Wellcome Trust, St. James University Hospital, Leeds, LS9 7TF, UK. E mail: @ leeds.ac.uk j.e.brown 1J.E.B. UKfor is grateful to Cancer Research from the award of a clinical scientist. The authors assume full responsibility for the content of this article and confirm to, that it reflects their views, and medical expertise. StemScientific gef Promoted by Bristol Myers Squibb, provided writing and editorial support. Bristol-Myers Squibb has no control over the content of the article, nor is the