Moreover, the presence of CD44+/CD24-/low tumor cells was associated with a
shorter cumulative DFS and OS, suggesting that the CD44+/CD24- phenotype may be an CAL-101 datasheet important factor of malignant relapse in patients with surgically resected invasive ductal carcinoma after chemotherapy. References 1. Jemal A, Siegel R, Xu J, Ward E: Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277–300.PubMedCrossRef 2. Ozbay T, Nahta R: Delphinidin inhibits HER2 and Erk1/2 signaling and suppresses I-BET-762 clinical trial growth of HER2-overexpressing and triple negative breast cancer cell lines. Breast Cancer: Basic and Clinical Research 2011, 5:143–154. 3. Voduc KD, Cheang MC, Tyldesley S, Gelmon K, Nielsen TO, Kennecke H: Breast cancer subtypes and the risk of local and regional relapse. J Clin Oncol 2010, 28:1684–1691.PubMedCrossRef 4. Reya T, Morrison SJ, Clarke MF, Weissman IL: Stem cells, cancer, and cancer stem cells. Nature 2001, 414:105–111.PubMedCrossRef 5. Nakshatri H, Srour EF, Badve S: Breast cancer stem cells and intrinsic subtypes: controversies rage on. Current Stem Cell Research & Therapy 2009, 4:50–60.CrossRef 6. Shipitsin M, Campbell LL, Argani AMN-107 order P, Weremowicz S, Bloushtain-Qimron N, Yao J, Nikolskaya T, Serebryiskaya
T, Beroukhim R, Hu M, Halushka MK, Sukumar S, Parker LM, Anderson KS, Harris LN, Garber JE, Richardson AL, Schnitt SJ, 4-Aminobutyrate aminotransferase Nikolsky Y, Gelman RS, Polyak K: Molecular definition of breast tumor heterogeneity. Cancer Cell 2007, 11:259–273.PubMedCrossRef 7. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 2008, 133:704–715.PubMedCrossRef 8. Visvader JE, Lindeman GJ: Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 2008, 8:755–768.PubMedCrossRef 9. Sorlie T,
Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale A: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001, 98:10869–10874.PubMedCrossRef 10. Sheridan C, Kishimoto H, Fuchs RK, Mehrotra S, Bhat-Nakshatri P, Turner CH, Goulet R, Badve S, Nakshatri H: CD44+/CD24- breast cancer cells exhibit enhanced invasive properties: an early step necessary for metastasis. Breast Cancer Res 2006, 8:R59.PubMedCrossRef 11. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003, 100:3983–3988.PubMedCrossRef 12.