Moxifloxacin Avelox powder danshen using an internal mixer

Acids in total polyphenolic fraction of Moxifloxacin  Avelox danshen S Was with the rat model of diabetes by streptozocin demonstrate biological activity of t, the study of its use in traditional medicine induced. Production of acids fraction of the total polyphenol. The dried root and rhizome of danshen from Zhixin China Pharmaceutical Co acquired, Ltd. has been pulverized into powder danshen using an internal mixer and 2 kg of powder was immersed in hot Em water for 3.5 h and filtered. The extract was washed with acetic Acid from 5% to pH 4.6 anges Acidified, and chromatographed on makropor Sen resin D 101 using deionized water, 50% and 95% ethanol, respectively, as eluent. The proportion of 50% ethanol was collected and condensed in the dried powder. The performance of the PAF was 5.16% acids, the Haupts Chlich polyphenol. High performance liquid chromatography analysis. A Dionex LC-20A series HPLC system with a C18 reversed-phase Zorbax SB was used to acquire HPLC chromatograms. PAF powder was dissolved in 100 ml of demineralized water St and 0.45 mm nylon syringe filter before the polyphenolic analysis. The mobile phase consisted of acetonitrile and South urel Methanolic solution The B using a linear gradient program from 10 A to 30 wt% 0 15 min, 30 to 45% A in 15 30 min, 45-80 min 30% A in Figure 50. The diode array detector was set nm to 286th For the analysis of tanshinones 0.025 g Rmiges PAF powdered gel in 50 ml of methanol St and through a nylon filter of 0.45 mm syringe. The mobile phase was methanol: water, and DAD detector was set nm to 270. The flowsheets rate was 1.0mL/min for both. An aliquot of 10 ml of the L Solution was injected for HPLC analysis. Animals. M Nnliche Sprague Dawley rats were obtained from Laboratory Animal Center of Guangzhou University of t obtained for Traditional Chinese Medicine. The study was conducted according to the guidelines for the care and use of laboratory animals, the Guangzhou University of t for Traditional Chinese Medicine, in accordance with internationally accepted standard guidelines for animal experiments. The animals were
again U is a standard pellet-di-t and water ad libitum under standard conditions and the environment were held. Pharmacological tests of diabetic rats. After 3 days of acclimatization, eight healthy rats continuously fed with normal and healthy as the other rats a high fat Di T, consisting of 10% fat, 10% sucrose, 10% egg yolk were fed 2% cholesterol, cholate and 0.25% 67.5% of the normal diet. After a month of di Tetischen manipulation, rats fed a di t high in fat I have Born for 12 h, and injected intraperitoneally with 30 mg / kg STZ fra YEARS Riger gel in 0.1 M acetate buffer St. Rats of group contr the standard solution were injected with buffer L. Three days after injection, fasting blood sugar was measured to the level best term diabetic. Rats with FBG levels between 11.1mm and 33.3mm were considered diabetic and were selected for pharmacological studies hlt. Four groups of rats were administered orally for 28 days as follows. The normal controlled group: normal rats administered 0.5% L solution of sodium carboxymethyl cellulose per day. Controlled group of diabetics Diabetic rats administered 0.5% CMCNa t Possible. Reference group: diabetic rats administered 26.7 mg / kg / day gliclazide. Group test:. Diabetic rats 187 mg / kg / day PAF

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