On one hand, these findings indicate a physiological function of Aβ-peptides. On the other hand, an Aβ-driven proinflammatory M1 polarization impairing phagocytosis may provide a model for self-sustained plaque deposition. The authors declare that they have no competing interests. J.M.M., M.H. and P.S. designed the study. M.C., J.M.M. and P.S. conducted the study and prepared the manuscript. M.H. provided expertise in interpreting the results of the flow cytometry-based phagocytosis assay. M.R.
isolated the porcine microglia. J.T.O. and J.K. reviewed the manuscript extensively CYC202 and provided constructive comments to improve the quality of the manuscript. All authors read and approved the final manuscript. This work is supported by Grants from the Interdisciplinary Center for Clinical Research ALK inhibitor (IZKF), Erlangen. The present work was performed in fulfillment of the requirements for obtaining the degree “Dr. med” of MC. “
“The number of obese (body mass index, BMI >30) and overweight
(BMI >25) people is reaching epidemic proportions worldwide. The World Health Organization reports that in 2008, more than 1.4 billion adults were overweight and over 200 million men and nearly 300 million women were obese (WHO, 2013). The prevalence of overweight and obese children and adolescents is also high. For example, during 2009–2010 the prevalence of childhood obesity was 16.9% in the United States of America (Ogden et al., 2012). Alarmingly, evidence shows that children who are overweight are more likely to remain so Tenoxicam in adulthood (Biro and Wien, 2010). It is well known that obesity increases the risk for a wide spectrum of conditions including type 2 diabetes, hypertension, heart disease, stroke, musculoskeletal disorders, gastrointestinal and respiratory problems, and many types of cancer (Haslam and James, 2005). In addition, relationships
between obesity and cognitive function, as well as risk of dementias such as Alzheimer’s disease (AD), have more recently come to attention. For example, clinical and experimental evidence indicates that obesity and/or high fat feeding are associated with deficits in learning, memory, and executive functioning (Elias et al., 2003, Elias et al., 2005, Cournot et al., 2006 and Sabia et al., 2009), and potentially brain atrophy (Enzinger et al., 2005 and Ward et al., 2005). Moreover, accumulating evidence indicates obesity during mid-life increases the risk of dementias such as AD later in life (Gorospe and Dave, 2007, Beydoun et al., 2008 and Anstey et al., 2011). In light of the high numbers of overweight and obese individuals, there is a clear need to better understand the pathophysiological mechanisms underpinning obesity and its impact on cognitive function.