The bacterial uptake of ofloxacin from hydrogels was higher than that obtained with a solution of free ofloxacin in both fluoroquinolone-sensitive and -resistant P. aeruginosa. The improved uptake in fluoroquinolone-resistant isolates was correlated with the viscosity of hydrogels. The performance of hydrogels seems to be related to their bioadhesive properties that allow prolonged contact time and find more the release of an effective
amount of drug close to bacterial cells. Hence, hydrogels could be used in the development of more effective formulations for topical administration of antibiotics. Improved performance of an old antibiotic can preserve the use of new generation fluoroquinolones.”
“Genital tuberculosis is often neglected by health-care providers, but is an important PP2 cell line cause of significant morbidity for the affected women.
We report a rare case of tuberculosis (TB) flare in a 28-year-old nulliparous woman following
endometrial aspiration (EA), which drained 30 ml pus. Following this, she developed high-grade fever with pain abdomen, guarding and rigidity. PCR was positive for mycobacterium and histopathology showed necrotizing granulomatous endometritis. She also showed features of genitourinary TB and chronic tubercular meningitis and was started on antitubercular therapy.
To conclude, EA requires concern and a higher precision in the diagnosis of this insidious disease that primarily necessitates a clinical awareness of this serious health problem, to prevent such flare-up of TB. The clinician should be aware that isolation of TB requires special methods and this diagnosis should be considered while dealing with patients born in countries with high prevalence
“Study Design. Case report.
Objective. We report the unusual case of a patient who was referred to our institution after she sustained an intraoperative injury to the common iliac vein during posterior lumbar discectomy at L5-S1 with a pituitary rongeur. There was only minimal bleeding with spontaneous hemostasis and no hemodynamic instability. Subsequently, the referring PD-L1 inhibitor surgeon noted that the pituitary rongeur tip was missing.
Summary of Background Data. Vascular injury during lumbar discectomy is a rare, but potentially devastating complication. Rapid diagnosis and treatment is traditionally targeted toward hemodynamic stabilization and repair of compromised structures.
Methods. Intraoperative fluoroscopy confirmed the presence of the tip anterior to the L3 vertebral body, indicating a possible intravascular migration of the foreign body. After completion of the surgical procedure, an abdominal computed tomography scan failed to confirm the metallic object within the abdominal cavity. Subsequent imaging studies demonstrated the presence of the rongeur tip in the left ventricle.