Rats were randomly allocated PRN1371 ic50 to 3 groups: Sham group (n = 20), DSP-4 [N-(-2-chloroethyl)-N-ethyl-2-bromobenzylamine] group (50 mg/kg ip, n = 18), and DSP-4
+ 5,7-DHT [5,7- dihydroxytryptamine] group (ip DSP-4 50 mg/kg + icv 5,7-DHT 200 mu g, n = 18). In Sham, DSP-4 and DSP-4 + 5,7-DHT groups, the effects of ip neurotropin (100 NU/Kg) on hot-plate latency in rats with no lesion, noradrenergic neuron depletion and both noradrenergic and serotonergic neuronal depletion were studied, respectively. Rats in each group were subdivided equally to 2 subgroups: saline and neurotropin. After completion of the hot-plate tests, each rat was decapitated, the cerebral cortex was dissected from its internal structure for measurement of norepinephrine contents. Hot-plate latency significantly decreased by similar to 40% 10 days after ip DSP-4 or after ip DSP-4 and 5,7-DHT. Norepinephrine contents in DSP-4 treated rats (55.6 +/- 6.3 ng/ng tissue) and DSP-4 + 5,7-DHT treated rats (35.3 +/- 6.3 ng/ng tissue) were significantly lower than those in intact rats (131.6 +/- 5.7 ng/ng tissue, p < 0.01). Neurotropin significantly increased
find more the area under the curve (AUC) of the hot-plate latency in the DSP-4 and DSP-4 + 5,7-DHT groups but not in the Sham group. There was a significant correlation between AUC and norepinephrine contents in saline subgroup (p < 0.01, r = 0.597) but not in neurotropin subgroup buy Mdivi1 in DSP-4 group. Neurotropin exerted an antinociceptive
effect in DSP-4 induced central neuropathic pain. The present data suggest neuronal pathways other than descending inhibitory noradrenergic and serotonergic systems may be involved in neurotropin mediated antinociception. (C) 2011 Elsevier Ireland Ltd. All rights reserved.”
“Aneurysms of the proper hepatic artery comprise a rare but potentially dangerous entity for which treatment is performed both surgically and endovascularly. Covered stents are generally used for endovascular treatment of such aneurysms. When the aneurysm is contaminated due to an enteric fistula, however, use of a covered stent is considered inappropriate. This case report describes the endovascular repair of a proper hepatic artery aneurysm using overlapping bare metal stents after the patient was surgically treated for duodenal hemorrhage. (J Vase Surg 2011;53:814-7.)”
“Tachykinin NK-2 receptor, a cognate receptor for neurokinin A, expressed in the brain has been suggested as a new target for the treatment of psychiatric disorders. In rodents, treatment with NK-2 receptor agonists causes anxiogenic effects, while NK-2 receptor antagonists show anxiolytic and antidepressant-like effects. However, information about the distribution and functions of NK-2 receptors in the central nervous system (CNS) in primates is still lacking.